Diabetes Clinical Trial
Official title:
Diabetic Wound Healing and Its Relationship to Vascular Circulation.
Diabetes mellitus is one of the leading causes of illness worldwide. Diabetes can affect nerves, skin and blood vessels. Diabetics with problems in their nerves can lose the sense of touch in their feet (called neuropathy) and so may unknowingly cause damage to the skin resulting in skin loss or an 'ulcer'. Diabetics also have difficulty healing any damaged tissues especially if the patients have diseased blood vessels causing a lack of blood to areas of the body including the feet (called ischaemia).
Diabetes mellitus is one of the leading causes of illness worldwide. Diabetes can affect
nerves, skin and blood vessels. Diabetics with problems in the patients nerves can lose the
sense of touch in the patient's feet (called neuropathy) and so may unknowingly cause damage
to the skin resulting in skin loss or an 'ulcer'. Diabetics also have difficulty healing any
damaged tissues especially if the patient have diseased blood vessels causing a lack of
blood to areas of the body including the feet (called ischaemia). Therefore diabetics have a
greater chance of having an ulcer and a higher chance that it does not heal up. The loss of
a protective skin barrier means that bacteria can enter the foot causing infections which
can spread to bone and beyond. Ultimately this can result in gangrene, amputation or even
death.
Stem or progenitor cells help repair and replace damage in the body. Blood vessels are key
to this repair. Recent research has suggested that special progenitor cells found in the
blood may be responsible. They are called Endothelial Progenitor Cells (EPCs) and seem to be
in fewer numbers and are less effective at repair in diabetics.
Current treatments for diabetic wounds are not always successful and so the investigators
need more research to look at new treatments. One possibility is to use electrical
stimulation of nerves in the leg. Research studies have shown this may improve blood
circulation and healing of wounds. This research will assess EPCs to see if they are linked
to ulcer healing in diabetic patients with neuropathy only or with ischaemia as well.
Furthermore the investigators wish to investigate whether electrical stimulation can affect
progenitor cells and wound healing in these patients. The longterm goal of this research is
to help diabetic patients improve their quality of life by reducing wound related
complications
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Prevention
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05594446 -
Morphometric Study of the Legs and Feet of Diabetic Patients in Order to Collect Data Intended to be Used to Measure by Dynamometry the Pressures Exerted by Several Medical Compression Socks at the Level of the Forefoot
|
||
Completed |
NCT03975309 -
DHS MIND Metabolomics
|
||
Completed |
NCT01855399 -
Technologically Enhanced Coaching: A Program to Improve Diabetes Outcomes
|
N/A | |
Completed |
NCT01819129 -
Efficacy and Safety of FIAsp Compared to Insulin Aspart in Combination With Insulin Glargine and Metformin in Adults With Type 2 Diabetes
|
Phase 3 | |
Recruiting |
NCT04984226 -
Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
|
Phase 2 | |
Recruiting |
NCT05007990 -
Caregiving Networks Across Disease Context and the Life Course
|
||
Active, not recruiting |
NCT04420936 -
Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care for Our Program
|
N/A | |
Recruiting |
NCT03549559 -
Imaging Histone Deacetylase in the Heart
|
N/A | |
Completed |
NCT04903496 -
Clinical Characteristics and Disease Burden of Diabetic Patients Based on Tianjin Regional Database
|
||
Completed |
NCT01437592 -
Investigating the Pharmacokinetic Properties of NN1250 in Healthy Chinese Subjects
|
Phase 1 | |
Completed |
NCT01696266 -
An International Survey on Hypoglycaemia Among Insulin-treated Patients With Diabetes
|
||
Completed |
NCT04082585 -
Total Health Improvement Program Research Project
|
||
Completed |
NCT03390179 -
Hyperglycemic Response and Steroid Administration After Surgery (DexGlySurgery)
|
||
Not yet recruiting |
NCT05029804 -
Effect of Walking Exercise Training on Adherence to Disease Management and Metabolic Control in Diabetes
|
N/A | |
Recruiting |
NCT05294822 -
Autologous Regenerative Islet Transplantation for Insulin-dependent Diabetes
|
N/A | |
Completed |
NCT04427982 -
Dance and Diabetes/Prediabetes Self-Management
|
N/A | |
Completed |
NCT02356848 -
STEP UP to Avert Amputation in Diabetes
|
N/A | |
Completed |
NCT03292185 -
A Trial to Investigate the Single Dose Pharmacokinetics of Insulin Degludec/Liraglutide Compared With Insulin Degludec and Liraglutide in Healthy Chinese Subjects
|
Phase 1 | |
Active, not recruiting |
NCT05477368 -
Examining the Feasibility of Prolonged Ketone Supplement Drink Consumption in Adults With Type 2 Diabetes
|
N/A | |
Completed |
NCT04496401 -
PK Study in Diabetic Transplant récipients : From Twice-daily Tacrolimus to Once-daily Extended-release Tacrolimus
|
Phase 4 |