Diabetes Mellitus, Type 2 Clinical Trial
Official title:
Role of Endoplasmic Reticulum Stress in the Pathophysiology of Type 2 Diabetes
The purpose of this study is to investigate whether Endoplasmic Reticulum (ER) stress
pathway is activated in peripheral tissues (adipose tissue) in insulin resistant diabetic
patients compared to healthy subjects normoglycemic matched for age and sex an to
investigate whether ER stress pathway can be activated in response to insulin. Indeed, some
preliminar on rates studies shows that ER stress pathway is activated by insulin in liver
and adipose tissue showing that hyperinsulinemia might help trigger stress path ER.
For this, we propose a case control study of type 2 diabetic patients vs control subjects in
which markers of ER stress will be evaluated from abdominal subcutaneous adipose tissue
obtained before and after euglycemic hyperinsulinemic. We chose to consider adipose tissue
subcutaneous rather than visceral adipose tissue for obvious reasons of lesser invasiveness.
n/a
Observational Model: Case Control, Time Perspective: Cross-Sectional
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