Diabetes Mellitus, Type 2 Clinical Trial
Official title:
Acute Effects of Inspiratory Muscle Exercise on Glucose Level and Glucose Variability in Patients With Type 2 Diabetes.
Type 2 diabetes is associated with respiratory muscle weakness and autonomic neuropathy. The exercise of inspiratory muscles has been investigating in various clinical situations and may cause similar benefits as the conventional exercises. The assessment of glucose variability has been used as an alternative tool to evaluate the others mechanisms than the absolute values of glucose levels, special during the exercise. However, the effect of inspiratory muscle exercise on glucose levels and glucose variability is not clear yet. The aim of the proposed research is to evaluate the acute effects of inspiratory muscle exercise using a high load of 60% of MIP on glucose levels and glucose variability in patients with type 2 diabetes.
High-intensity exercise of inspiratory muscle was able to reduce glucose levels in previous
studies, but the mechanisms underlying this reduction remain largely unknown. The present
study will investigate this phenomenon, and whether confirmed, the inspiratory muscle
loading would be a new approach for lowering glucose levels and glucose variability in type
2 diabetes.
The subjects with type 2 diabetes will be recruited from the ambulatory of the Hospital de
Clinicas de Porto Alegre. The patients will be randomized to inspiratory muscle exercise
with a high intensity load (MIP 60%) or to exercise with a load placebo (MIP 2%), on two
different days. The subjects will come in the laboratory for three days consecutively during
2 weeks. On the first day will be placed the CGMS device. On the second day will be the
controlled ventilation protocol with subsequently inspiratory muscle exercise, using 2% or
60% of MIP as randomized a priori. On the third day the CGMS will be removed. Individuals
who are using beta-blockers will be advised to withdraw the medication 24 hours before the
protocols. During all protocols will be recorded the continuous blood pressure to assess
heart rate and blood pressure variabilities, both time and frequency domains will be
analyzed. Also, the calf blood flow, inspiratory pressure, end-tidal carbon dioxide and
oxygen saturation will be taking.
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Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Investigator, Outcomes Assessor)
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