ADA Linagliptin in Long Term Care

Status Completed

Clinical Trial Summary

This is a study to determine whether glycemic control, as measured by change in HbA1c and frequency of hypoglycemia, is different between treatment with linagliptin (Tradjenta®) and basal insulin in long term care residents(LTC) with Type 2 diabetes(T2D). Patients with poorly controlled diabetes (HbA1c >7.5%) will be randomized to a 6-month intervention with linagliptin or glargine insulin (± metformin for both treatments). Our hypothesis is that treatment with linagliptin, a once daily DPP4-inhibitor, will result in similar improvement in glucose control but in a lower rate of hypoglycemia than insulin treatment in LTC residents with T2D. We will also determine differences in clinical outcome, resource utilization, and hospitalization costs between LTC residents with T2D treated with linagliptin and basal and correction insulin. We will compare differences in complications (infectious and non-infectious, neurological and cardiovascular events), emergency room visits and hospitalizations between groups during the 6 months of intervention.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Diabetes

Clinical Trial Details

NCT number	NCT02061969
Study type	Interventional
Source	Emory University
Contact
Status	Completed
Phase	Phase 4
Start date	April 25, 2014
Completion date	April 10, 2017

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