Diabetes Mellitus, Type 2 Clinical Trial
Official title:
Diagnosis and Physiopathology of Insulin Allergy (IA)
Insulin allergy (IA) is still observed even with recombinant human insulin and insulin
analogs.
Obviously, the usual attitude facing an allergy, i. e. exclusion of the allergen, poses
problems in face of IA because insulin is often vital for the patient. IA is thus a complex
situation in which a rigorous diagnostic procedure to identify the exact allergen is
necessary to propose a therapeutic answer; the purpose of the study is 1/ to validate a
diagnostic algorithm for patients presenting with possible allergy. 2/ to investigate
immunogenetic profiles of patient with insulin allergy 3/ cellular mechanisms of IA.
Phenotype of the patient Investigation of allergy per intradermal testing using a wide range of insulin preparations Determination of immunologic and immunogenetic profile particularly CD4 + T cells and mast cells ;
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