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NCT01372852 Clinical Trial

Plasma Adiponectin Concentration, Activity and Isoforms in Newly Diagnosed and Untreated Type 2 Diabetes Mellitus

Diabetes Mellitus Clinical Trial

Official title:
Plasma Adiponectin Concentration, Activity and Isoforms in Newly Diagnosed and Untreated T2DM Patients in Chinese Population

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT01372852
Other study ID # xjyy110501
Secondary ID
Status Recruiting
Phase N/A
First received June 11, 2011
Last updated June 13, 2011
Start date May 2010
Est. completion date December 2011

Study information
Verified date May 2010
Source Xijing Hospital
Contact Ling Tao, M.D Ph.D
Phone +86-15002955798
Email lingtao2006@gmail.com
Is FDA regulated No
Health authority China: Food and Drug Administration
Study type Observational

Clinical Trial Summary

The objective of present study were to compare plasma adiponectin isoform status, their bioactivities newly diagnosed Chinese with healthy volunteer.

Description:

Adiponectin, circulates as trimer, hexamer and high molecular weight form (HMW) in human blood, is a promising biomarker for indication diabetes and cardiovascular disease. Both adiponectin complexes concentration and their bioactivities are decreased in pathological state. Disulfide-bond A oxidoreductase-like protein (DsbA-L) is a key regulator for adiponectin biosynthesis and its expression level is down-regulated in obese mice and humans. However, the alteration of circulating adiponectin multimers distribution, their bioactivities and adiponectin regulator, DsbA-L level, in newly diagnosed Chinese type 2 diabetes patients are unknown. The objective of present study were to compare plasma adiponectin isoform status, their bioactivities and DsbA-L concentration in newly diagnosed Chinese with healthy volunteer.

Recruitment information / eligibility
Status Recruiting
Enrollment 300
Est. completion date December 2011
Est. primary completion date October 2011
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 30 Years to 70 Years
Eligibility Inclusion Criteria:

- Having a diabetic history within 12 months

- BMI smaller than 30kg/m2

Exclusion Criteria:

- Having any kinds of treatment affecting glucose

- pregnant

- uncontrolled hypertension, active cardiac disease, or other major liver, kidney disease

Study Design

Observational Model: Cohort, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
China Xijing Hospital Xi'an Shaanxi

Sponsors (1)
Lead Sponsor Collaborator
Xijing Hospital

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary plasma adiponectin concentration, isoform distribution and activity. participants will be followed for the duration of hospital stay, an expected average of 1 week No
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