Diabetes Mellitus Clinical Trial
Official title:
Effect of Cinnamon on Gastric Emptying, Arterial Stiffness, Postprandial Lipaemia, Glycaemia, and Appetite Responses to High-fat Breakfast
The purpose of this study is to determine whether 3 g cinnamon was sufficient to delay the gastric emptying rate of a high-fat solid meal and subsequently reduce postprandial blood glucose and lipid responses, oxidative stress, arterial stiffness and satiety responses in a healthy adult population.
Cinnamon has been shown to delay gastric emptying (GE) of a high-carbohydrate meal and
reduce postprandial glycaemia in healthy adults. However, it is dietary fat which is
implicated in the etiology and is associated with obesity, type 2 diabetes (T2D) and
cardiovascular disease (CVD). We aimed to determine the effect of 3 g cinnamon on GE,
postprandial lipemic and glycemic responses, oxidative stress, arterial stiffness, as well
as appetite sensations and subsequent food intake following a high-fat (HF) meal.
The effect of acute oral administration of 3 g cinnamon on gastric emptying of a high-fat
pancake test meal and subjective appetite sensations by visual analogue scale will be
measured for six hours postprandially. During this time course, measurements of postprandial
lipemic, glycemic, oxidative stress and arterial stiffness responses will be collected.
Subsequently, food intake will be measured using an ad libitum buffet meal. The study will
be conducted in a randomized, placebo-controlled, single-blinded manner in 9 healthy
subjects.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
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