Diabetes Clinical Trial
| NCT number | NCT01242137 |
| Other study ID # | 169/09 |
| Secondary ID | |
| Status | Recruiting |
| Phase | N/A |
| First received | November 14, 2010 |
| Last updated | November 15, 2010 |
| Start date | October 2009 |
Glibenclamide is metabolized by the hepatic enzyme P450 CYP2C9 to less active form.
Polymorphism of this enzyme demonstrated clinical significance when examined on other drugs
from the sulfonylurea drug family, to whom Glibenclamide is included.
The investigators assumption is that patients with less active alleles of the enzyme may
show lower dose requirements of the drug for glycemic control, when compared to patients
homozygotes to wild-type alleles.
| Status | Recruiting |
| Enrollment | 30 |
| Est. completion date | |
| Est. primary completion date | |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 20 Years to 90 Years |
| Eligibility |
Inclusion Criteria: - Tx with metformin and glibenclamide Exclusion Criteria: - Tx which affecting the P450 2C9 action - Renal failure |
Observational Model: Case Control, Time Perspective: Prospective
| Country | Name | City | State |
|---|---|---|---|
| Israel | Assaf Harofe Medical Center | Beer Yakov |
| Lead Sponsor | Collaborator |
|---|---|
| Assaf-Harofeh Medical Center |
Israel,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | HbA1c | 2 years | No |
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