Clinical Trials Logo

Clinical Trial Summary

Islets of Langerhans intended for clinical transplantation are labelled with a radioactive tracer. The tracer is retained in viable cells of the transplant. At infusion (transplantation) of the islets into the portal vein the tracer can be followed for two hours with positron emission tomography (PET). Imaging and calculations can give estimates of the proportion of surveying islets and the rate of early destruction. Also the distribution of the islets into the liver can be viewed.


Clinical Trial Description

Background:

It is suspected that the current need for repeated islets transplantation to treat diabetes type I is dependent on an early destruction of the islets when infused into the portal vein.

Aim:

To trace the fate of the islet at and after infusion into the portal vein.

Method:

Islets are labelled in vitro with a radioactive tracer that can be measured with positron emission tomography. 10-20 percent of the graft is labelled. Just prior to start of infusion labelled islets are mixed with unlabelled islets (80-90 percent of the graft). The tracer used is FDG and stands for 2-[18F]-2-deoxy-D-glucose. At infusion the patient is placed in the combined computer tomography and PET camera to follow the infusion. The imaging is almost continuous for 2 h at and after infusion.

Expected results:

Calculations of proportion of surviving islets and rate of destruction. Localisation and distribution of islets in the liver of the recipient. ;


Study Design

Observational Model: Cohort, Time Perspective: Prospective


Related Conditions & MeSH terms


NCT number NCT00417131
Study type Observational
Source Uppsala University Hospital
Contact
Status Completed
Phase N/A
Start date October 2006
Completion date November 2010

See also
  Status Clinical Trial Phase
Recruiting NCT02546401 - Comparison of Insulin's Injection Before or After the Meal in Type 1 Diabetic Patients Treated With Insulin Pump Phase 3
Enrolling by invitation NCT06207838 - Transition of T1DM Patients Aged Over 65 Years Into AHCL (780G) Insulin Pump N/A
Withdrawn NCT02057497 - An Exploratory Clinical Trial to Generate Whole Blood Samples for Analysing Genetic Polymorphisms N/A
Active, not recruiting NCT05088616 - Native American Diabetes Project N/A
Withdrawn NCT01501032 - Inpatient Evaluation of the MD-Logic Artificial Pancreas System in Patients With Type 1 Diabetes Phase 1
Completed NCT01770561 - Feasibility Study of an Integrated Sensor and Infusion Set N/A
Completed NCT03538106 - Factors Associated With Cesarean Delivery in Women With Type 1 Diabetes
Completed NCT01565824 - Web-based Support During Pregnancy and Early Motherhood in Women With Type 1 Diabetes (MODIAB-web) N/A
Recruiting NCT04257877 - Proteomic Analysis in Paediatric Diabetes Type 1 (PAPD)
Withdrawn NCT01322321 - ACZ885 in Type 1 Diabetes Mellitus Phase 2
Active, not recruiting NCT04794283 - Antenatal Hand Milking for Pregnant Women With Diabetes'
Completed NCT03842683 - CGM Precision and Glycaemic Variability
Suspended NCT04874532 - A Study to Improve Diabetes Management Among Adults Experiencing Severe Hypoglycemia N/A
Terminated NCT00925977 - Treatment Satisfaction of Insulin Glargine Plus Insulin Apidra Compared With NPH Insulin Plus Insulin Apidra in Recently Diagnosed Type 1 Diabetes Children and Adolescents N/A
Completed NCT02066350 - Cardiovascular Risk Factors After Single Pancreas Transplantation N/A
Completed NCT02137174 - Home and School Visits Intervention for Children With DM TYPE 1 Phase 2/Phase 3
Completed NCT06365255 - National Epidemiological Study of the Possible Impact of Stress on Glycaemic Control in Patients With Type 1 Diabetes
Completed NCT03433677 - A Study of LY900014 and Insulin Lispro With an External Continuous Subcutaneous Insulin Infusion System in Adult Participants With Type 1 Diabetes Phase 3
Completed NCT04587297 - Food Collection From Type 1 Diabetic Patients Practicing Insulin Functional Therapy
Completed NCT02490124 - The Effect of Type 1 Diabetes on Pan-Arterial Vascular Function and Insulin Sensitivity in Humans N/A