Microvascular Reactivity.

Diabetes Clinical Trial

Official title:

Transdermal Application of Acetylcholine and Nitroglycerin Without Iontophoresis.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00259701
• Other study ID #: HIC-12397-1
• Status: Completed
• Phase: N/A
• First received: November 28, 2005
• Last updated: October 5, 2006
• Start date: June 2005
• Est. completion date: September 2005

Study information

• Verified date: November 2005
• Source: Yale University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

This study attempts to test capillary responses to various challenges without the need for iontophoresis (electrical current).

Description:

Studies of microvascular responsiveness often employ iontophoresis to fascilitate drug absorption. Iontophoresis is a confounding stimulus in such studies, and we are attempting to create tests of the microvasculature that do not require iontophoretic drug delivery.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: September 2005
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria: diabetic. -

Exclusion Criteria: not on nitrates or mydriatic eye drops within 48 hours.

Study Design

Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Diabetes
• Retinopathy
• Vascular Pathology

Intervention

Device:
• Laser Doppler Flowmetry with topical acetylcholine and nitroglycerin

Locations

Country	Name	City	State
United States	Yale School of Medicine	New HAven	Connecticut

Sponsors (1)

Lead Sponsor	Collaborator
Yale University

Country where clinical trial is conducted

United States,