Diabetes Mellitus Clinical Trial
Official title:
Long Term Follow-Up of Diabetic Retinopathy
The efficacy of laser photocoagulation treatment for diabetic retinopathy has been
demonstrated by several National Eye Institute (NEI) sponsored clinical trials. The Diabetic
Retinopathy Study (DRS) demonstrated that scatter photocoagulation reduces the risk of
blindness from diabetic retinopathy. The Early Treatment Diabetic Retinopathy Study (ETDRS)
extended these findings by providing information on when to initiate scatter
photocoagulation and by demonstrating that focal treatment was effective in treating macula
edema. The Krypton Argon Regression Neovascularization Study (KARNS) showed that scatter
photocoagulation with krypton red laser was just as safe and effective as the argon
blue-green laser in the treatment of proliferative diabetic retinopathy.
Unfortunately, there is little data on the long term effects of photocoagulation on visual
function. The first objective of this study is to assess the long term effects of
photocoagulation for diabetic retinopathy. A second objective is to provide additional
information on the risk of progression of cataracts in persons with diabetes. All patients
previously treated with laser photocoagulation (focal and/or scatter) are eligible to
participate in this long term study. The first priority will be given to patients who
participated in the ETDRS and KARNS because of the wealth of information available regarding
the details of their treatment and course after treatment. Study evaluations will include a
standard ophthalmic examination, fluorescein angiography, lens and fundus photography.
The efficacy of laser photocoagulation treatment for diabetic retinopathy has been
demonstrated by several National Eye Institute (NEI) sponsored clinical trials. The Diabetic
Retinopathy Study (DRS) demonstrated that scatter photocoagulation reduces the risk of
blindness from diabetic retinopathy. The Early Treatment Diabetic Retinopathy Study (ETDRS)
extended these findings by providing information on when to initiate scatter
photocoagulation and by demonstrating that focal treatment was effective in treating macula
edema. The Krypton Argon Regression Neovascularization Study (KARNS) showed that scatter
photocoagulation with krypton red laser was just as safe and effective as the argon
blue-green laser in the treatment of proliferative diabetic retinopathy.
Unfortunately, there is little data on the long term effects of photocoagulation on visual
function. The first objective of this study is to assess the long term effects of
photocoagulation for diabetic retinopathy. A second objective is to provide additional
information on the risk of progression of cataracts in persons with diabetes. All patients
previously treated with laser photocoagulation (focal and/or scatter) are eligible to
participate in this long term study. The first priority will be given to patients who
participated in the ETDRS and KARNS because of the wealth of information available regarding
the details of their treatment and course after treatment. Study evaluations will include a
standard ophthalmic examination, fluorescein angiography, lens and fundus photography.
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