Regulation of Brain Glucose Metabolism in Type 1 Diabetes

Status Not yet recruiting

Clinical Trial Summary

This is a prospective randomized placebo-controlled double-blind crossover study determining the effect of dichloroacetate on brain glucose metabolism under clamped hypoglycemia in T1DM.

Clinical Trial Description

This study is a prospective randomized placebo-controlled double-blind crossover study designed to address the hypothesis that dichloroacetate has the ability to re-activate brain glucose metabolism under clamped hypoglycemia. The study population is comprised of intensively treated persons with T1D with frequent exposure to hypoglycemia, who have cognitive deficits under hypoglycemia that could be attributed to changes in brain glucose oxidation. The investigators will test the experimental compound DCA in a mechanistic study that determines whether brain metabolism is restored by this intervention, or whether the drug effect was primarily caused by changes in physiology outside of the brain. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05317455
Study type	Interventional
Source	Yale University
Contact	Alice Hahn
Phone	4753210504
Email	alice.hahn@yale.edu
Status	Not yet recruiting
Phase	Early Phase 1
Start date	January 2024
Completion date	May 2024

View Details

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