Diabetes Mellitus Clinical Trial
Official title:
Pilot Evaluation of PCR Multiplex Tests for a Rapid Diagnosis of Bone Infections in Diabetic Foot
Bone samples from infected diabetic feet will be collected and tests will be performed for the diagnosis of causative bacteria. Samples will be processed by PCR multiplex tests and usual cultures for identification of causative bacteria and sensitivity to antibiotics. Results obtained by the two methods will be compared in terms of quickness and similarity of germ identification. Usual care strategy will not be modified since results of PCR multiplex tests will not be transmitted to the physicians before the results of usual cultures.
This study will investigate the quickness of identification of bacteria causing bone
infection in the feet of patients with diabetes from bone samples obtained by biopsies
performed in usaual care practice.
Bone biopsies will be performed in patients diagnosed for osteomyelitis from clinical,
biological and MRI signs. Bone samples will be collected in Ultra-Turrax® tubes in the
operating theater before being transferred to the department of bacteriology. Time of
registration at the bacteriology lab will be considered as Time 0 (T0).
Samples will be processed simultaneously using the usual culture method and by PCR Multiplex
tests.
The time of identification of causative bacteria for bone infection (time 1, T1) and the time
of identification of sensitivity/resistance to antibiotics (time 2, T2) by the two different
methods will be recorded.
Identified germs and their sensitivity/resistance to antibiotics according to the two methods
will be compared.
If the results are similar, the time that could be gained for the prescription of specific
antibiotics from PCR multiplex tests' results will be computed in comparison to the
prescription performed from the results of usual cultures.
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