Diabetes Mellitus, Type 2 Clinical Trial
Official title:
Effect of Inspiratory Muscle Training on Glycemic Control in Individuals With Type 2 Diabetes:Randomized Clinical Trial
In diabetic individuals, changes in ventilatory muscle strength and lung function have been demonstrated over the years. The onset and progression of chronic complications in diabetes should be avoided by reaching glycated hemoglobin (HbA1c) levels below 7%. The control of glycemia through the measurement of HbA1c is fundamental to avoid complications. The inspiratory muscle training has been used in several clinical situations, and may be an alternative for individuals with type 2 diabetes mellitus who have difficulties performing conventional exercises. The long-term effect of inspiratory muscle training on glycemic control has not been tested yet. The aim of this study is to evaluate the effects of inspiratory muscle training on glycemic control in individuals with type 2 diabetes.
An acute high intensity inspiratory muscle exercise session was able to reduce glycemic
levels (24%) similarly to an aerobic exercise session (25%) in subjects with type 2 diabetes,
demonstrating that this type of exercise inspiratory muscle may have great potential in
improving glycemic control.The present study will investigate if training of the inspiratory
musculature for 8 and 12 weeks is capable of improving glycated hemoglobin, glucose and
inspiratory muscle strength in individuals with type 2 diabetes. In addition, this study will
evaluate the effect of inspiratory muscle training, with moderate loading of 30% of the MIP,
on volumes and capacities lung in patients with type 2 diabetes. The subjects with type 2
diabetes will be recruited from the ambulatory of the Hospital de Clinicas de Porto Alegre
and through newspaper advertisements.
Patients will be submitted to a general evaluation, including clinical history, physical
examination, laboratory evaluation and application of the international physical activity
questionnaire. Subsequently, individuals will perform assessments of lung functions (lung
function assessment, ventilatory muscle strength test, inspiratory muscle strength test) and
autonomic assessment (Ewing's tests). Patients will be randomized to perform inspiratory
muscle training with a placebo load (MIP 2%) or with moderate intensity (MIP 30%). Upon the
randomization, participants will initiate inspiratory musculature training. The exams of
HbA1c, glucose and ventilatory muscle strength tests will be performed in three moments: 1)
at the initial assessment, 2) in the eighth week of inspiratory muscle training, and 3) at
the end of the training (twelfth) week. During inspiratory muscle training, individuals will
attend on Hospital de Clinicas de Porto Alegre, once a week, to the supervision of the way
the exercise is being performed. Furthermore, it will be set to load on the PowerBreathe ®
device for the following week.
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