Diabetes Mellitus, Type 2 Clinical Trial
Official title:
Interval-training and Appetite Regulation in Patients With Type 2 Diabetes
Four months of interval walking (IW) training results in substantial weight loss in
opposition to energy-expenditure matched continuous walking (CW) training. The reason for
this is unclear.
This study will assess if IW leads to greater exercise-induced suppression of appetite and
ad libitum food intake compared to CW and no exercise.
Subjects with type 2 diabetes will be included in a crossover, counter-balanced, controlled
study, where each subject will undergo three trials. Trials will be identical except the
following interventions:
1. One hour of rest (CON)
2. One hour of interval walking (repeated cycles of 3 min of fast and 3 min of slow
walking; IW)
3. One hour of continuous walking (CW) matched to IW with regards to energy-expenditure.
After the interventions subjects will undergo a liquid mixed meal tolerance test (450 kCal),
with regular measurements of appetite-related hormones (insulin, ghrelin, Leptin,
Cholecystokinin, PYY). Three hours into the mixed meal tolerance test, a standardised
ad-libitum meal test will be served and intake will recorded. Free-living energy intake via
food records will be assessed during the following 32 hours.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
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