Diabetes Mellitus Clinical Trial
Official title:
A Study Utilising Tissue From Deceased Organ Donors to Investigate Regenerative Cellular Therapies and Related Physiological and Developmental Processes
This study aims to use tissue from deceased organ donors to investigate organ physiology, developmental biology, as well as the development of future regenerative cellular therapies. It will investigate function and immune response to stem cells as well as their generation from adult cells and generation of induced pluripotent stem cells (iPSCs).
The purpose of this study is to use tissue from deceased organ donors to address questions
that are of importance for the development of regenerative cellular therapies for better
understanding of organ physiology and developmental biology. This study aims to maximise the
clinically available data as well as patient benefit that can be generated from donated
tissue. It also aims to reduce number of consent forms given to patients by consolidating
and coordinating a number of related investigations.
The study aims are:
- To examine function and the immune response to stem cells and their differentiated
progeny as well as development of immunomodulatory approaches to prevent their
rejection.
- Generation of induced pluripotent stem cells (iPSCs) and their subsequent
differentiation into functional cells as potential therapies.
- Generation of differentiated cells from native adult stem cells as cellular therapies.
- Investigation of organ physiology.
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Observational Model: Cohort, Time Perspective: Prospective
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