Dexmedetomidine Clinical Trial
Official title:
Systemic Versus Local Dexamedetomedine as An Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Block in Kidney Exploration Surgeries ,A Randomized Controlled Trial
The aim of this study is to investigate the analgesic effect of local versus systemic dexamedetomedine as adjuvant to bupivacaine in erector spinae block in kidney exploration surgeries.
Status | Recruiting |
Enrollment | 75 |
Est. completion date | June 1, 2024 |
Est. primary completion date | June 1, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility | Inclusion Criteria: •. kidney exploration surgeries. - ASA I/II patients. - BMI <35 Exclusion Criteria: - Getting opioid analgesics prior to surgery. - Local infections at the site where needle for block is to be inserted. - ASAIII/IV. - Pregnancy. - History of drug addiction or alcohol abuse or a psychiatric illness, |
Country | Name | City | State |
---|---|---|---|
Egypt | Aswan University | Aswan |
Lead Sponsor | Collaborator |
---|---|
Aswan University |
Egypt,
Forero M, Adhikary SD, Lopez H, Tsui C, Chin KJ. The Erector Spinae Plane Block: A Novel Analgesic Technique in Thoracic Neuropathic Pain. Reg Anesth Pain Med. 2016 Sep-Oct;41(5):621-7. doi: 10.1097/AAP.0000000000000451. — View Citation
Wang Q, Li H, Wei S, Zhang G, Ni C, Sun L, Zheng H. Dexmedetomidine Added to Ropivacaine for Ultrasound-guided Erector Spinae Plane Block Prolongs Analgesia Duration and Reduces Perioperative Opioid Consumption After Thoracotomy: A Randomized, Controlled Clinical Study. Clin J Pain. 2021 Oct 12;38(1):8-14. doi: 10.1097/AJP.0000000000000992. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The duration of analgesia, this was defined as the time in minutes to the first request for postoperative analgesics. | The duration of analgesia, this was defined as the time in minutes to the first request for | at 60 , 180 minutes | |
Secondary | 2. Total postoperative opioid consumption (Nalbuphine consumption (mg) within the 48-hour period . | 2. Total postoperative opioid consumption (Nalbuphine consumption (mg) within the 48-hour period. | at 1, 3, 6, 12, 24, 36 and 48 hours | |
Secondary | Ramsay Sedation Scale (RSS) (1: anxious; 2: cooperative and tranquil; 3: responding to command; 4: brisk response to stimuli; 5: sluggish response to stimuli; and 6: no response to stimuli) will be all assessed | amsay Sedation Scale (RSS) The RSS is a user-friendly and therefore commonly used sedation scale, with scores ranging from +4 (a violent dangerous patient) to -5 (an unarousable patient).6 A sedation score of 0 is most often therapeutically targeted, as it correlates with an alert and calm patient. | at 1, 3, 6, 12, 24, 36 and 48 hours | |
Secondary | Intraoperative hemodynamic parameters blood pressure | blood pressure measurement obtained by non-invasive blood pressure cuff during intraoperative and postoperative in PACU expressed in mmhg | at 1, 3, 6, hours | |
Secondary | Minimum alveolar concentration (MAC) requirements | Minimum alveolar concentration or MAC is the concentration, often expressed as a percentage by volume, of a vapour in the alveoli of the lungs that is needed to prevent movement (motor response) in 50% of subjects in response to surgical (pain) stimulus. | during intraoperative periods expressed in minutes |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04577430 -
Effects of Dexmedetomidine on Cardiac Electrophysiology in Patients Under General Anesthesia During Perioperative Period
|
N/A | |
Completed |
NCT03220880 -
Intranasal Dexmedetomidine Sedation in Children for Non-painful Procedures
|
||
Completed |
NCT05291364 -
Dexmedetomidine in Splanchnic Nerve Neurolysis
|
N/A | |
Recruiting |
NCT05249153 -
Dexmedetomidine and Sufentanil Effect in PCA on Pediatric Patients Undergoing Scoliosis Surgery
|
N/A | |
Completed |
NCT01688648 -
Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft
|
N/A | |
Completed |
NCT05103735 -
Propofol-remifentanyl Versus Dexmedetomidine in Awake Craniotomy: Impact on Electroclinical Seizure Activity
|
||
Recruiting |
NCT06030804 -
Perioperative Dexmedetomidine and Long-term Survival After Cancer Surgery
|
N/A | |
Terminated |
NCT03253224 -
Magnesium and Postoperative Pain
|
Phase 4 | |
Recruiting |
NCT06210061 -
Propofol-Fentanyl-Dexmedetomidine and Propofol-Fentanyl-Sevoflurane Anesthesia for Major Spine Surgery Under Somato Sensory- and Motor- Evoked Potential Monitoring
|
N/A | |
Recruiting |
NCT05525819 -
Intrathecal Versus Intravenous Dexmedetomidine in Prostate Transurethral Resection
|
N/A | |
Completed |
NCT04665453 -
Dexmedetomidine and Melatonin for Sleep Induction for EEG in Children
|
N/A | |
Completed |
NCT06018948 -
Effect of Two Different Doses of Dexmedetomidine Infusion in Morbidly Obese Patients
|
Phase 4 | |
Completed |
NCT03658421 -
Dexmedetomidine as Adjuvant for FNB in TKA
|
N/A | |
Completed |
NCT03775655 -
Low Dose Hyperbaric Bupivacaine and Dexmedetomidine as an Adjuvant, Caesarean Section
|
Phase 2/Phase 3 | |
Completed |
NCT03234660 -
Dexmedetomidine and Neuroprotection in Children Undergoing General Anesthesia
|
N/A | |
Completed |
NCT06020781 -
Efficacy and Safety of Dexmedetomidine to Bupivacaine in Supraclavicular Brachial Plexus Block
|
N/A | |
Recruiting |
NCT06207331 -
Effects of Atomized Dexmedetomidine on Lung Function in Patients With Chronic Obstructive Pulmonary Disease
|
N/A | |
Active, not recruiting |
NCT03629262 -
Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery
|
Phase 4 | |
Completed |
NCT06098209 -
Dexmedetomidine and Propofol in Mechanically Ventilated Patients by Using Salivary Alpha-amylase as a Stress Marker
|
N/A | |
Not yet recruiting |
NCT06062550 -
Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery
|
Phase 4 |