Dexmedetomidine Clinical Trial
Official title:
Crossover Pharmacokinetic Study of Two Mode of Administration of Intranasal Dexmedetomidine in Healthy Adult Volunteers
Intranasal dexmedetomidine has been studied and used in children for premedication before
anaesthesia or fro sedation. It can be administered by simple dripping or by Mucosal
Atomization Device (MAD®).
Since MAD® delivers intranasal medication in a fine mist, it is possible that absorption and
bioavailability would be better compares to simple dripping method. To date no
pharmacokinetic information of intranasal dexmedetomidine delivered by either method is
available. This investigation is designed to compare the bioavailablity of intranasal
dexmedetomidine deliver via simple dipping with tuberculine syringe and MAD® in healthy
adults.
This is a three-period crossover double-blinded study. 8 subjects will be recruited and they will attend 3 study sessions after informed written and verbal consent. They would have dexmedetomidine administered via different rout each time, intravenous, intranasal via dripping or intranasal via atomizer. Blood samples are collect to determine bioavailability of each mode of drug delivery. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04577430 -
Effects of Dexmedetomidine on Cardiac Electrophysiology in Patients Under General Anesthesia During Perioperative Period
|
N/A | |
| Completed |
NCT03220880 -
Intranasal Dexmedetomidine Sedation in Children for Non-painful Procedures
|
||
| Completed |
NCT05291364 -
Dexmedetomidine in Splanchnic Nerve Neurolysis
|
N/A | |
| Recruiting |
NCT05249153 -
Dexmedetomidine and Sufentanil Effect in PCA on Pediatric Patients Undergoing Scoliosis Surgery
|
N/A | |
| Completed |
NCT01688648 -
Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft
|
N/A | |
| Completed |
NCT05103735 -
Propofol-remifentanyl Versus Dexmedetomidine in Awake Craniotomy: Impact on Electroclinical Seizure Activity
|
||
| Recruiting |
NCT06030804 -
Perioperative Dexmedetomidine and Long-term Survival After Cancer Surgery
|
N/A | |
| Terminated |
NCT03253224 -
Magnesium and Postoperative Pain
|
Phase 4 | |
| Recruiting |
NCT06210061 -
Propofol-Fentanyl-Dexmedetomidine and Propofol-Fentanyl-Sevoflurane Anesthesia for Major Spine Surgery Under Somato Sensory- and Motor- Evoked Potential Monitoring
|
N/A | |
| Recruiting |
NCT05525819 -
Intrathecal Versus Intravenous Dexmedetomidine in Prostate Transurethral Resection
|
N/A | |
| Completed |
NCT04665453 -
Dexmedetomidine and Melatonin for Sleep Induction for EEG in Children
|
N/A | |
| Completed |
NCT06018948 -
Effect of Two Different Doses of Dexmedetomidine Infusion in Morbidly Obese Patients
|
Phase 4 | |
| Completed |
NCT03775655 -
Low Dose Hyperbaric Bupivacaine and Dexmedetomidine as an Adjuvant, Caesarean Section
|
Phase 2/Phase 3 | |
| Completed |
NCT03658421 -
Dexmedetomidine as Adjuvant for FNB in TKA
|
N/A | |
| Completed |
NCT03234660 -
Dexmedetomidine and Neuroprotection in Children Undergoing General Anesthesia
|
N/A | |
| Completed |
NCT06020781 -
Efficacy and Safety of Dexmedetomidine to Bupivacaine in Supraclavicular Brachial Plexus Block
|
N/A | |
| Recruiting |
NCT06207331 -
Effects of Atomized Dexmedetomidine on Lung Function in Patients With Chronic Obstructive Pulmonary Disease
|
N/A | |
| Active, not recruiting |
NCT03629262 -
Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery
|
Phase 4 | |
| Completed |
NCT06098209 -
Dexmedetomidine and Propofol in Mechanically Ventilated Patients by Using Salivary Alpha-amylase as a Stress Marker
|
N/A | |
| Not yet recruiting |
NCT06062550 -
Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery
|
Phase 4 |