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Dermatitis clinical trials

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NCT ID: NCT06390878 Recruiting - Atopic Dermatitis Clinical Trials

Nationwide Research on the Rewilding of Kindergarten Yards

Vahvistu
Start date: May 1, 2024
Phase: N/A
Study type: Interventional

Biodiversity is essential for nature and human well-being. Land use has reduced biodiversity in cities that is associated with altered commensal microbiota and a rising burden of immunological disorders among urban children. The investigators will estimate how rewilding of kindergarten yards affects commensal microbiome, prevalence of allergies, asthma, atopic dermatitis and infections, cortisol levels, cognitive skills and plasma cytokine levels of children. Our specific aims are: To assess if rewilding diversifies health-associated skin, saliva and gut microbiota and reduces infectious diseases and atopic or allergic symptoms. Assess whether the rewilding has positive effects on cognitive skills. Assess whether the rewilding changes cortisol and plasma cytokine levels. The investigators will recruit altogether 320 (160 per treatment) study subjects aged between 1-5 to questionnaire study (Task 2), from which 120 study subjects will be analyzed more detailed using microbiological and blood samples (Task 1).

NCT ID: NCT06390696 Recruiting - Atopic Dermatitis Clinical Trials

Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis

BIWE
Start date: May 26, 2023
Phase: N/A
Study type: Interventional

The prevalence of atopic dermatitis has increased along with urbanization and biodiversity loss. According to biodiversity hypothesis, the main reason is urban lifestyle and reduced contact to microbial diversity. Previous studies indicate association between atopic dermatitis and exposure to natural microbes in childhood. Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis will investigate whether the exposure to microbial diversity in sandbox reduces the symptoms of atopic dermatitis, alters commensal microbiota and modifies immune regulation in children.

NCT ID: NCT06387472 Recruiting - Contact Dermatitis Clinical Trials

DermAI to Evaluate Human Factor of Testing

Start date: April 29, 2024
Phase: N/A
Study type: Interventional

The purpose of this research is to improve how well remote patch allergy testing works and make sure they are easy and practical for people to use from home.

NCT ID: NCT06383468 Recruiting - Atopic Dermatitis Clinical Trials

A Phase III Study to Evaluate the Efficacy and Safety of AK120 in Patients With Moderate to Severe Atopic Dermatitis

Start date: April 30, 2024
Phase: Phase 3
Study type: Interventional

This is a randomized double-blind, placebo-controlled, multicenter phase III clinical study evaluating the efficacy and safety of AK120 injection in the treatment of patients with moderate to severe atopic dermatitis.

NCT ID: NCT06366932 Recruiting - Atopic Dermatitis Clinical Trials

Optimization of Atopic Dermatitis Treatment That Requires Second-line Systemic Therapy Through Predictive Models

Start date: September 25, 2023
Phase: Phase 4
Study type: Interventional

This is a low-intervention phase IV trial. The main objective is to optimize the treatment of patients with moderate-severe atopic dermatitis that require systemic treatment after failure, intolerance or contraindication to cyclosporine.

NCT ID: NCT06363461 Recruiting - Atopic Dermatitis Clinical Trials

Study of TDM-180935 in Atopic Dermatitis Patients

Start date: April 13, 2024
Phase: Phase 2
Study type: Interventional

Randomized, Vehicle-controlled, Parallel Group Study of TDM-180935 in Atopic Dermatitis Patients

NCT ID: NCT06345404 Recruiting - Atopic Dermatitis Clinical Trials

Safety, Tolerability, and Preliminary Efficacy of Soquelitinib in Participants With Moderate to Severe AD

Start date: April 2024
Phase: Phase 1
Study type: Interventional

Safety, tolerability, and preliminary efficacy of soquelitinib in participants with moderate to severe AD

NCT ID: NCT06331390 Recruiting - Contact Dermatitis Clinical Trials

Assessment of Niacinamide Cosmetic Product Efficacy in Model of Irritant Contact Dermatitis

Start date: April 2024
Phase: N/A
Study type: Interventional

Testing the effectiveness and safety of cosmetics with niacinamide in irritant contact dermatitis: A Randomised, Controlled Trial will be conducted at USSM. Healthy volunteers will be included (at least 25) and test sites are forearms. Sodium lauryl sulphate will be used to induce contact dermatitis and participants will be measured for 7 days

NCT ID: NCT06319781 Recruiting - Psoriasis Clinical Trials

A Pilot Cohort Study of Risk Factors and Novel Methods of Skin Lesion Assessments in Adults With Atopic Dermatitis, Alopecia Areata, Psoriasis or Vitiligo

Derma-001
Start date: December 15, 2023
Phase:
Study type: Observational

The objective of the study is to explore various clinical and biochemical parameters and their potential associations with disease severity, activity, and prognosis in atopic dermatitis, psoriasis, alopecia areata, and vitiligo. Further, the study aims at validating remote assessments of skin lesions, using smartphone-acquired photos. The study will also assess the feasibility and compliance with weekly remote-assessments and patient-reported data collection over the full study period of one year. The study will observe patients through a period of one year and will provide detailed information concerning the type and dose of medication used, as well as data to evaluate the disease activity with high resolution during this period. The study will involve collection of serum samples for exploratory biomarkers, and punch biopsies. A total of approximately 370 patients, divided into the four disease areas of atopic dermatitis, alopecia areata, psoriasis, and vitiligo, will be enrolled in the study. Using a combination of self-reported and on-site assessments and procedures, the intent is to observe the natural history of patients with select dermatological conditions, investigate tissue characteristics associated with disease activity and symptoms, and evaluate the validity of remote assessment of lesions, and feasibility of weekly self-acquired smart-phone images of skin lesions for remote assessment.

NCT ID: NCT06313333 Recruiting - Atopic Dermatitis Clinical Trials

National Register of Moderate and Severe Adult Atopic Dermatitis

ATOPYREG
Start date: June 15, 2020
Phase:
Study type: Observational [Patient Registry]

Collect clinical history and treatment data of AD in adulthood;