Dermatitis, Atopic Clinical Trial
Official title:
Effect of Dietary Milk Phospholipids on Subjects With Atopic Dermatitis
The aim of the study is to investigate the influence of a milk phospholipid enriched dairy product on subjects with atopic dermatitis determining parameters of the immune status, the plasma lipid profile and the skin texture.
Based on the facts, that on the one hand milk phospholipids are characterized by a high
sphingolipid content and on the other hand a disturbed sphingolipid metabolism in the
epidermis of patients with atopic dermatitis was verified, a double blinded, controlled,
randomized, cross-over study with a daily supplementation of 3 g milk phospholipids to
subjects with a mild to moderate atopic dermatitis will be conducted.
Forty patients will be randomized between two groups of each 20 patients. After an
individual checkup and a run-in period of 2 weeks, the one group will receive the
phospholipid enriched dairy product and the second group will be given a placebo dairy
product over two month. A wash out-period of 4 weeks will follow, and the patients will
consume the contrary dairy products over two month after a 2-week run-in period again.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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