Effect of Different Skin Creams on TEWL

Status Completed

Clinical Trial Summary

Clinical Trial Description

Prospective, single center, clinical pilot study to test the hypothesis that lipid rich EpiCeram® is superior in improving skin barrier function compared to Aveeno Daily Moisturising Sheer Hydration Lotion®. Primary Objective: To compare skin barrier function, assessed by TEWL AUC, between non-lesional areas of the skin treated with EpiCeram®, Aveeno Daily Moisturising Sheer Hydration Lotion® or no emollient use for one week. Secondary Objectives: To assess lipid and protein profiles of skin tape strips from non-lesional skin, after a week of either EpiCeram®, Aveeno Daily Moisturising Sheer Hydration Lotion® or no treatment. Exploratory Objectives : - To study whether the effects on TEWL on lesional and non-lesional skin persist 24 hours after cessation of therapy. - To evaluate whether baseline food and environmental allergy sensitization (assessed via skin prick testing during screening) affects the outcomes. See protocol section 3.1 for allergen details. - A central repository of blood samples will be stored for future use to assess plasma biomarkers to help characterize clinical outcome data. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03663673
Study type	Interventional
Source	Stanford University
Contact
Status	Completed
Phase	Phase 1
Start date	September 1, 2018
Completion date	July 18, 2019

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