Dermatitis, Atopic Clinical Trial
Official title:
Clinical Evaluation of the Effect of Moisturising Cream on Skin Moisture in Atopic Dermatitis
The aim of this study is evaluate the effect of three moisturising creams on Stratum corneum (SC) hydratation and barrier function.
In the present study, 24 subjects with AD will be treated for 3 weeks twice daily by using 3
different moisturising creams. Duration of the study is based on literature. Various
moisturising creams containing glycerol have been reported to be beneficial for AD lesions.
The optimal glycerol content in moisturising creams is not known. The secondary objective is
the comparison of change in the SC water content and in the TEWL from the skin surface from
the baseline to the end of study between different moisturizing creams containing different
amount of glycerol.
Change in the SC water content and in the TEWL can be demonstrated with noninvasive
instrumental measurement. The treated skin will be followed up instrumentally, and one
measurement area will serve as an untreated control. The primary evaluation is the
comparison of change in the SC water content and in the TEWL on the skin surface from the
baseline to the end of study between the 4 treatments.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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