Depressive Symptoms Clinical Trial
Official title:
Effect of Subanesthetic Dose of Ketamine Combined With Propofol on Cognitive Function in Depressive Patients Undergoing Electroconvulsive Therapy ---a Randomized Control Double-Blind Clinical Trial
Electroconvulsive therapy (ECT) is an effective treatment for depression compared with the current antidepressant agents,but the most important side effect is cognitive dysfunction. The purpose of this study is to determine whether subanesthetic dose of ketamine combined with propofol is superior to propofol anesthesia alone in improving cognitive function in depressive patients undergoing ECT.
Depression is one of the most debilitating and widespread illnesses affecting up to 20% of
individuals in their lifetime. However, the current antidepressant agents take weeks to
work, and fail to help at least 40% of depressed patients. Electroconvulsive therapy (ECT)
is a remarkably effective treatment for depression, but its use is limited by cognitive
dysfunction.
As a result, it is becoming a clinical problem which need to be settled urgently. Previous
clinical study showed that subanesthetic dose of ketamine could play a role in
antidepressant effects with safety and minimal positive psychotic symptoms.The investigators
also found that subanesthetic dose of ketamine combined with other anesthetics could improve
cognitive function in depressive rats receiving electroconvulsive shock (a model for analogy
with ECT). Few clinical researches concerned the effects of subanesthetic dose of ketamine
combined with propofol anesthesia on cognitive function in patients after ECT, therefore the
investigators conduct this randomized controlled double-blind trial. In this study,
cognitive function will be rated by Mini-Mental State examination score.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
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