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An Adaptive Algorithm-Based Approach to Treatment for Adolescent Depression

Depressive Disorder Clinical Trial

Official title:
An Adaptive Algorithm-Based Approach to Treatment for Adolescent Depression

Clinical Trial Summary

The purpose of this study is to evaluate the effectiveness of two adaptive treatment strategies (ATSs) for adolescent depression. The ATSs include delivery of an evidence-based psychotherapy (interpersonal psychotherapy for depressed adolescents, IPT-A), systematic symptom monitoring, and an empirically-derived algorithm that specifies whether, when, and how to augment IPT-A. Two hundred depressed adolescents (age 12-18) will be recruited to participate in a 16-week sequential multiple assignment randomized trial conducted in outpatient community mental health clinics. Adolescents will be randomized to the IPT-A ATS condition or the community clinic's usual care (UC). Adolescents in the IPT-A ATS condition who are insufficient responders will be randomized a second time to the addition of a selective serotonin reuptake inhibitor (SSRI) or more intensive IPT-A (delivered twice per week). Research assessments will be administered at baseline and at weeks 4, 8, 12, 16, and 36.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03222570
Study type Interventional
Source University of Minnesota
Contact Meredith Gunlicks-Stoessel, Ph.D.
Phone 612-273-9844
Email mgunlick@umn.edu
Status Recruiting
Phase Phase 2
Start date February 26, 2018
Completion date December 2024
View Details
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