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Positive Affect Treatment for Adolescents With Early Life Adversity — PAT4ELA  

Depression Clinical Trial

Official title:
Mitigating Depression Among Adversity Exposed Adolescents Using Positive Affect Therapy

Clinical Trial Summary

Youth exposed to early life adversity (ELA) are known to be at greater risk for depression and suicidality and account for almost half of the youth suffering from psychiatric diseases today. Youth exposed to ELA consistently report symptoms of anhedonia as well as dysregulated positive affect. The present project will test the efficacy of PAT in a sample of ELA-exposed adolescents in order to determine whether PAT increases positive affect, and subsequently symptoms of depression. For this pilot, the investigators will recruit 22 adolescents exposed to two or more childhood adversities (ACEs) who do not currently have major depressive disorder, and randomize them (1:1) to either participate in PAT or a waitlist control condition. At study enrollment, then 4-, 8, and 12-months thereafter the investigators will measure positive affect and depressive symptoms (including anhedonia). The results of this study will be used to inform whether PAT has the potential to prevent major depressive episodes among adversity-exposed youth.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06273137
Study type Interventional
Source University of California, Irvine
Contact Kate R Kuhlman, Ph.D.
Phone 9498245574
Email krkuhl@uci.edu
Status Recruiting
Phase N/A
Start date February 3, 2024
Completion date October 16, 2026
View Details
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