Impact of Light on Mood

Depression Clinical Trial

Official title:

More Than Meets the Eye? The Impact of Light on Mood Regulation in Humans

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06027944
• Other study ID #: IRB-71791
• Status: Not yet recruiting
• Phase: N/A
• Start date: October 1, 2023
• Est. completion date: September 30, 2024

Study information

• Verified date: September 2023
• Source: VA Palo Alto Health Care System
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators are examining whether the content of a visual scene impacts the antidepressant effects of light or if this impact is solely mediated by the intensity of the light.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 20
• Est. completion date: September 30, 2024
• Est. primary completion date: September 30, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Aged 18-60

• Mild depressive symptomatology

Exclusion Criteria:

• No depressive symptomatology

• Severe depressive symptomatology

• Active or unstable medical condition

• Diabetes

Related Conditions & MeSH terms

• Depression

Intervention

Other:
• Light exposure
Participants will be exposed to 15 minutes of each arm. They will be exposed twice and a randomized order (1/2/1/2 or 2/1/2/1)

Locations

Country	Name	City	State
United States	VA Palo Alto Health Care System	Palo Alto	California

Sponsors (2)

Lead Sponsor	Collaborator
VA Palo Alto Health Care System	Stanford University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in mood	Change in subjective mood as recored by the Positive and Negative Affect Schedule (PANAS). The PANAS ranges 10-50 on a positive mood scale (higher = more positive) and 10-50 on a negative mood scale (higher = more negative)	15 minutes
Secondary	Change in fast brain electrical activity	Change in the beta power spectrum (12.5-30 Hz) of the electroencephalogram (brain waves, measured in microvolts)	15 minutes
Secondary	Change in systolic blood pressure (SBP)	Change in SBP (mm Hg) as measured by finger plethysmography	15 minutes
Secondary	Change in heart rate variability (HRV)	Shift in the ratio of the power of low frequency to high frequency components in heart rate variability	15 minutes
Secondary	Change in sympathetic activity	Sympathetic activity will be imputed through the galvanic skin response (GSR). Change in skin conductance (the electrical activity on the skin) will be measured in microsiemens	15 minutes