Anaerobic Exercise and Mental Acuity

Depression Clinical Trial

Official title:

Anaerobic Exercise as a Modulator of Microbial Composition and Mental Acuity in Sedentary Men

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05850221
• Other study ID #: STUDY00017316
• Status: Completed
• Phase: N/A
• Start date: April 15, 2023
• Est. completion date: November 15, 2023

Study information

• Verified date: May 2024
• Source: Arizona State University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This is a randomized controlled trial to examine the effect of anaerobic activity (e.g., weight training) on gut microbiome metabolism and neurological health in healthy sedentary men.

Description:

The human gut microbiome, which houses over 2,000 distinct bacterial species, has recently been characterized as a highly influential force on the health and longevity of its host. By way of several distinct pathways comprising the "microbiome-gut-brain axis", this diverse population is known to communicate with the human brain in a bidirectional manner and is implicated in the pathophysiology of several metabolic and psychological disease states. The ability to support a healthy, diverse microbiome through modifiable behavioral interventions - such as diet and exercise - is a topic of growing interest. Most of the evidence pertaining to the relationship between physical activity and the gut-brain axis at this time, however, investigates the influence of aerobic exercise providing limited insight to how other modalities of physical activity may differ. Specifically, this study will examine the impact of an 8-week weight training protocol on gut microbiome metabolism and neurological health in healthy sedentary men. Participants will be randomly assigned to the intervention group or the waitlist control group.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 23
• Est. completion date: November 15, 2023
• Est. primary completion date: October 15, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• free of any existing medical diagnoses

• willing and able to participate in moderate to vigorous exercise as determined by the ACSM Health/Fitness Facility Preparticipation Screening Questionnaire

• sedentary (defined as a score <14 on the Godin-Shepard Leisure Time Physical Activity Questionnaire (GSLTQ))

• equipped with access to a complete gym

Exclusion Criteria:

• antibiotic use within the past six months

• prebiotic, probiotic, or high-dose antioxidant supplementation within the past 6 months

• smoker (cigarettes and/or marijuana)

• regular laxative use

• blood pressure >129/80 at baseline

Related Conditions & MeSH terms

• Depression
• LPS
• Mood

Intervention

Other:
• weight training
weight training

Locations

Country	Name	City	State
United States	850 PBC	Phoenix	Arizona

Sponsors (1)

Lead Sponsor	Collaborator
Arizona State University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	anaerobic capacity	wingate test	change from baseline at week 8
Primary	gut barrier integrity	serum LPS binding protein	change from baseline at week 8
Secondary	mood state	Depression score on Center for Epidemiological Studies-Depression (CES-D) questionnaire.; Scores range from 0-60, with scores >15 indicating an elevated risk of depression and scores >30 indicating elevated symptoms of depression that may influence the health of the individual	change from baseline at week 8