Clinical Trial Details
— Status: Not yet recruiting
Administrative data
| NCT number |
NCT05184959 |
| Other study ID # |
2021-1069 |
| Secondary ID |
|
| Status |
Not yet recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
February 1, 2022 |
| Est. completion date |
December 1, 2022 |
Study information
| Verified date |
December 2021 |
| Source |
Second Affiliated Hospital, School of Medicine, Zhejiang University |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational [Patient Registry]
|
Clinical Trial Summary
High-dose benzodiazepines can inhibit the central nervous system, respiratory system and
cardiovascular motor center, resulting in loss of consciousness, disappearance of reflex,
respiratory inhibition, decrease of blood pressure and so on. This kind of drug acute
poisoning is the most common drug poisoning in internal medicine. It has acute onset and
severe symptoms. If it is not treated properly in time, it can be life-threatening. At
present, the research on the accumulation and metabolic state caused by benzodiazepine
poisoning is not sufficient; at the same time, the changes of neuroendocrine metabolism and
immune function of patients with neuroendocrine metabolism and immune function need to be
further explored. Therefore, the main purpose of this study is to analyze the effects of
neuroendocrine metabolism and immune function on organ function and mental state in patients
with benzodiazepine poisoning.
Description:
Benzodiazepines are the first choice for clinical anti-anxiety, sedation and hypnosis, as
well as anticonvulsant, antiepileptic and central muscle relaxation. Commonly used are
diazepam (diazepam), nitro diazepam, clonazepam, alprazolam, triazolam and so on. The drug
itself is an inhibitor of the central nervous system, which has a high selectivity for the
inhibition of the central nervous system, mainly inhibiting the limbic system of the brain
and less inhibitory effect on the reticular ascending activation system. It mainly acts on
the synaptic sites of GABA-Ergic nerve endings in the central nervous system. It enhances the
affinity between GABA and its receptors by binding to benzodiazepine receptors, thus
increasing the open frequency of Cl- channels coupled with GABA receptors and exerting an
inhibitory effect. High-dose benzodiazepines can inhibit the central nervous system,
respiratory system and cardiovascular motor center, resulting in loss of consciousness,
disappearance of reflex, respiratory inhibition, decrease of blood pressure and so on. This
kind of drug acute poisoning is the most common drug poisoning in internal medicine. It has
acute onset and severe symptoms. If it is not treated properly in time, it can be
life-threatening. At present, the research on the accumulation and metabolic state caused by
benzodiazepine poisoning is not sufficient; at the same time, the changes of neuroendocrine
metabolism and immune function of patients with neuroendocrine metabolism and immune function
need to be further explored. Therefore, the main purpose of this study is to analyze the
effects of neuroendocrine metabolism and immune function on organ function and mental state
in patients with benzodiazepine poisoning.
