Depression Clinical Trial
— sequelaeOfficial title:
Treating Sequalae Caused by Post-acute Sequelae of SARS (Severe Acute Respiratory Syndrome)-CoV-2 Infection
Post-acute sequelae of SARS-CoV-2 infection can cause multiple system function disorders, and complicated symptoms last for an extended period. The virus can cause this continued infection, or the virus causes immune system function disorder and post-infectious autoimmune disease. The clinical symptoms can be smell loss, taste loss to liver function disorder, kidney function failure, different. No matter how complicated the systems showed in the clinic, all of the symptoms are due to the specific cells being damaged. Our clinical study is focused on recovering the damaged structure and function of the cells that could restore the organ function back to normal or close to normal
Status | Recruiting |
Enrollment | 2000 |
Est. completion date | October 1, 2022 |
Est. primary completion date | May 1, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion Criteria: - The participants must receive medical herbs as a treatment method; - Participants are not limited by age, sex, race, or location; - Participants are including infants; - Participants are including pregnant woman; - The participants had an infection history of SARS-CoV-2 in past one month; - The participants provide SARS-CoV-s diagnoses (Molecular or Antigen). Test was *positive, now hold negative reports - Participants hold reports of immune system medics, like immunoglobulin M (IgM), immunoglobulin G (IgG); - Reports that is evidence of specific organ damaged, including assay reports or image reports - Participants must agree to take medical herbs for at least 3 months as one course continually; - Participants must agree to repeat the assay and image test to monitor the treatment results; - Participants must report their Manifestations clearly to investigators; - Participants must agree to continue the next course of the treatment after the evaluation if it is necessary; - The treatment goal is to become symptom-free, and experiment assays went to normal Exclusion Criteria: - Participants don't want to take medical herbs; - Participants have symptoms of sequelae but is not caused by SARS-CoV-2 (COVID-19); - Participants have not symptoms after COVID-19 infection, no assays abnormal either; - Participants don't want to repeat the experiment assays; - Participants are in E.R. or ICU during the application or enrollment; |
Country | Name | City | State |
---|---|---|---|
United States | All Natural Medicine Clinic, LLC | Rockville | Maryland |
Lead Sponsor | Collaborator |
---|---|
All Natural Medicine Clinic, LLC |
United States,
Fujinami RS, von Herrath MG, Christen U, Whitton JL. Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease. Clin Microbiol Rev. 2006 Jan;19(1):80-94. Review. — View Citation
Honda T, Egen JG, Lämmermann T, Kastenmüller W, Torabi-Parizi P, Germain RN. Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues. Immunity. 2014 Feb 20;40(2):235-247. doi: 10.1016/j.immuni.2013.11.017. Epub 2014 Jan 16. — View Citation
Jurewicz MM, Stern LJ. Class II MHC antigen processing in immune tolerance and inflammation. Immunogenetics. 2019 Mar;71(3):171-187. doi: 10.1007/s00251-018-1095-x. Epub 2018 Nov 12. Review. — View Citation
Ploumpidis D. Living with covid-19. Psychiatriki. 2020 Jul-Sep;31(3):197-200. doi: 10.22365/jpsych.2020.313.197. English, Greek, Modern. — View Citation
Pollard CA, Morran MP, Nestor-Kalinoski AL. The COVID-19 pandemic: a global health crisis. Physiol Genomics. 2020 Nov 1;52(11):549-557. doi: 10.1152/physiolgenomics.00089.2020. Epub 2020 Sep 29. Review. — View Citation
Schvartz A, Belot A, Kone-Paut I. Pediatric Inflammatory Multisystem Syndrome and Rheumatic Diseases During SARS-CoV-2 Pandemic. Front Pediatr. 2020 Dec 4;8:605807. doi: 10.3389/fped.2020.605807. eCollection 2020. Review. — View Citation
Smatti MK, Cyprian FS, Nasrallah GK, Al Thani AA, Almishal RO, Yassine HM. Viruses and Autoimmunity: A Review on the Potential Interaction and Molecular Mechanisms. Viruses. 2019 Aug 19;11(8). pii: E762. doi: 10.3390/v11080762. Review. — View Citation
Wang F, Kream RM, Stefano GB. Long-Term Respiratory and Neurological Sequelae of COVID-19. Med Sci Monit. 2020 Nov 1;26:e928996. doi: 10.12659/MSM.928996. Review. — View Citation
Wannzhu Hou Cellular Structure and its Function is the key for keeling Diseases, Certification and Registration number: TXu 1-938-144 July 30, 2014
Wanzhu Hou, et al. Treating Autoimmune disease with Chinses Medicine, Elsevier, 2011
Zigmond E, Varol C, Farache J, Elmaliah E, Satpathy AT, Friedlander G, Mack M, Shpigel N, Boneca IG, Murphy KM, Shakhar G, Halpern Z, Jung S. Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. Immunity. 2012 Dec 14;37(6):1076-90. doi: 10.1016/j.immuni.2012.08.026. Epub 2012 Dec 6. — View Citation
* Note: There are 11 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Monitoring symptoms | Measuring the symptoms of chest pain, cough, loss of smell, loss of taste by Visual Analog Score (VAS) | 3 months as a course | |
Secondary | Monitoring emotion changing | measuring anxiety, depression, bipolar feeling by Visual Analog Score (VAS) | 3 months as a course. | |
Secondary | Checking heart burn symptom | Measuring stomach reflux symptom by Visual Analog Score (VAS) | 3 months as a course. | |
Secondary | Monitoring thyroid function | Measuring thyroid hormone3, 4 (T3,T4), thyroid-stimulating hormone (TSH) level | 3 months as a course | |
Secondary | Monitoring liver function | Measuring alanine transaminase (ALT), Aspartate transaminase (AST), alkaline phosphatase (ALP) recovering | 3 months as a course | |
Secondary | Monitoring kidney function | Measuring estimated glomerular filtration rate (eGFR), creatinine (Cr.) level | 3 months as a course |
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