Understanding How Anaesthesia Affects ECT Outcomes

Depression Clinical Trial

Official title:

Understanding How Anaesthesia Affects ECT Outcomes

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03105245
• Other study ID #: HREC16952
• Status: Completed
• Phase: Phase 3
• Start date: March 15, 2017
• Est. completion date: March 15, 2019

Study information

• Verified date: March 2023
• Source: The University of New South Wales
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will examine how anaesthetic technique affects ECT outcomes. Specifically, the investigators will examine how: 1) the time interval between anaesthetic and ECT stimulus, and 2) the ventilation rate before ECT stimulus, impacts on the quality of the EEG (this is a recording of brain activity during ECT and is used to judge the quality of a seizure and to guide individual patient dosing).

Description:

This study aims to examine how the time interval between administration of anaesthetic agent and ECT stimulus delivery impacts upon measures of EEG quality (seizure quality).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 54
• Est. completion date: March 15, 2019
• Est. primary completion date: March 15, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients treated with a course of ECT

Exclusion Criteria:

• Use of non-standard anaesthetic agents in ECT (e.g. ketamine)

Related Conditions & MeSH terms

• Depression

Intervention

Other:
• Electroconvulsive Therapy (ECT) time interval + Anaesthetic (Thiopentone)
The intervention in this study is the time interval between anaesthetic administration and ECT stimulus

Locations

Country	Name	City	State
Australia	Wesley Hospital Kogarah	Sydney	New South Wales

Sponsors (2)

Lead Sponsor	Collaborator
The University of New South Wales	Wesley Mission

Country where clinical trial is conducted

Australia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	EEG Seizure Quality Rating using the EEG Seizure Quality Rating Sheet utilised by MacPherson et al	EEG quality will be rated manually for each ECT treatment undertaken by a participant until the conclusion of their ECT course. This rating will be done using the EEG Seizure Quality Rating Sheet utilised by MacPherson et al - low dose lignocaine added to propofol does not attenuate the response to electroconvulsive therapy; Journal of Affective Disorders, 2010; 126: 330-333	Outcome measures will be collected immediately after each ECT treatment from the first treatment until the end of the ECT course, an estimated total of four to six weeks for most participants