Cognitive Correlates of Antidepressant Treatment Response in Elders

Status Completed

Clinical Trial Summary

Major depression is a very common health problem affecting older persons. The present standard of treatment is with medications called "antidepressants". Antidepressants have been studied extensively in older persons with normal brain function and have been shown to be effective. However, certain types of brain dysfunction called "executive impairment" (inability to do higher order thinking) may lead to poor treatment outcomes. This study will compare how older depressed people with different levels of executive impairment respond differently to standard antidepressant treatment. Knowing this information will lead to more rational targeting of available treatments, leading to improved treatment outcomes.

Clinical Trial Description

n/a

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Depression

Clinical Trial Details

NCT number	NCT01477268
Study type	Interventional
Source	St. Michael's Hospital, Toronto
Contact
Status	Completed
Phase	Phase 4
Start date	June 2007
Completion date	October 2009

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