Depression Clinical Trial
Official title:
Low Dose Ketamine for Low Mood States: An Emergency Department Feasibility Study for Depressed Patients
NCT number | NCT01209845 |
Other study ID # | 0909005766 |
Secondary ID | |
Status | Completed |
Phase | Phase 1 |
First received | |
Last updated | |
Start date | April 2010 |
Est. completion date | December 2010 |
Verified date | August 2020 |
Source | Yale University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The investigators hope to see if a commonly used drug such as ketamine could help depressed ER patients feel better and improve their mood quickly.
Status | Completed |
Enrollment | 14 |
Est. completion date | December 2010 |
Est. primary completion date | December 2010 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - adults (>18yrs) presenting to the Emergency department with symptoms of depression and/or suicide ideation (MADRS>30) with ability to give informed consent. - medically stable Exclusion Criteria: - psychosis, bipolar, or other significant physical or mental illness - pregnancy - non-voluntary status - urine drug screen positive for drugs of abuse |
Country | Name | City | State |
---|---|---|---|
United States | Yale New Haven Hospital Emergency Department | New Haven | Connecticut |
Lead Sponsor | Collaborator |
---|---|
Yale University |
United States,
Larkin GL, Beautrais AL. A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department. Int J Neuropsychopharmacol. 2011 Sep;14(8):1127-31. doi: 10.1017/S1461145711000629. Epub 2011 May 5. Retraction — View Citation
Larkin GL, Beautrais AL. A Preliminary Naturalistic Study of Low-Dose Ketamine for Depression and Suicide Ideation in the Emergency Department. Int J Neuropsychopharmacol. 2017 Jul 1;20(7):611. doi: 10.1093/ijnp/pyx035. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Montgomery Asberg Depression Rating Scale (MADRS) | The MADRS measures mood (depression) and item 10 measures suicide ideation. | 40, 80, 120, 240 minutes after administration of drug | |
Secondary | recruitment success and retention of subjects in the ER | All patient subjects are admitted and we will follow them in the hospital and for 2 weeks after hospital discharge. | initial recruitment of eligible subjects in the ER and for two weeks after administration of drug |
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