Depression Clinical Trial
Official title:
A Study of Transcranial Magnetic Stimulation (TMS) Treatment in Depressed Adolescents
This is a study to assess the effectiveness and safety of repetitive transcranial magnetic
stimulation (rTMS) as a treatment for depressed 13-18 year olds.
In rTMS high-intensity, fluctuating magnetic fields non-invasively stimulate the cortex of
the brain depolarizing neurons. No anesthetic is required and the treatment in
subconvulsive. Recent studies suggest that rTMS can be an effective treatment for depressive
illness in adults (Loo and Mitchell, 2005) and appears to be quite safe.
Minimal data of TMS use in adolescents psychiatric disorders. Data only existed in seven
patients of the four that were depressed two showed improvement in their depression
(Quintana, 2005). No sham-controlled studies have been conducted.
The investigators wish to assess this in a sham-controlled study of 30 adolescents. The
investigators hypothesize that rTMS will have an antidepressant effect and produce no
neuropsychological impairment.
The study has two phases: the sham-controlled phase and an open phase.
Sham-controlled Phase
Participants are randomly assigned to an active or sham TMS condition.
Open Phase
Following the sham controlled period participants participants in the sham rTMS condition
will be offered active rTMS. Participants will have the opportunity to receive up to 6 weeks
of active rTMS.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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