Switching to Duloxetine to Ameliorate SSRI-Induced Sexual Dysfunction

Status Terminated

Clinical Trial Summary

Sexual dysfunction is a common side effect of selective serotonin reuptake inhibitors (SSRIs). The hypotheses of this study are that:1. subjects with major depression or dysthymia who are being treated with an SSRI and experiencing treatment-related sexual dysfunction will experience less sexual dysfunction if they are switched to duloxetine, and 2. they will experience either improved antidepressant response or no loss of antidepressant response.

Clinical Trial Description

In this study, subjects suffering from depression or dysthymia and experiencing treatment-emergent sexual dysfunction from an SSRI are switched from their SSRI to duloxetine to determine whether or not they experience improved sexual function and equal or improved antidepressant response. Study subjects are assigned to receive open label duloxetine for 12 weeks at either 60mg per day or 120mg per day after discontinuing their current antidepressant ;

Study Design

Related Conditions & MeSH terms

Depression

Clinical Trial Details

NCT number	NCT00398632
Study type	Interventional
Source	Stanford University
Contact
Status	Terminated
Phase	Phase 4
Start date	November 2006
Completion date	April 2009

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