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Dental Pulp Necrosis clinical trials

View clinical trials related to Dental Pulp Necrosis.

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NCT ID: NCT05522270 Not yet recruiting - Necrotic Pulp Clinical Trials

Concentrated Growth Factor Versus Platelet Rich Fibrin in Revitalization of Necrotic Young Permanent Incisors

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

Regenerative endodontic procedures (REPs) are the most recent proposal to manage immature permanent teeth with necrotic pulps. So in this study, the investigator will evaluate the clinical and radiographical revitalization success in necrotic young permanent anterior teeth of participants by using Concentrated Growth Factor versus Platelet-Rich Fibrin

NCT ID: NCT05419752 Not yet recruiting - Necrotic Pulp Clinical Trials

Clinical Assessment of 3 Differant Obturation Sealers on Postoprative Pain and Swelling

Start date: July 30, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

aim of the study will be conducted to compare the effect of MTA fill apex sealer and endo sequence bioceramic sealer in obturation on the intenisty of postoperative pain and the incidence of post operative swelling in patient with necrotic teeth .

NCT ID: NCT05348824 Not yet recruiting - Necrotic Pulp Clinical Trials

Effect of Moringa Oleifera Leaf Extract on Postoperative Pain and Bacterial Reduction in Mandibular Premolars

Start date: August 2022
Phase: Phase 2/Phase 3
Study type: Interventional

The aim of this study is to clinically compare the intensity of post-operative pain and the amount of bacterial reduction after using Moringa oleifera leaf extract solution during chemo-mechanical preparation, versus 2.5% NaOCl, in asymptomatic necrotic mandibular premolars treated in a single visit

NCT ID: NCT05305417 Not yet recruiting - Periapical Diseases Clinical Trials

Cell-free Autologous Regenerative Endodontics Treatment for Teeth With Periapical Lesions (CARETT)

CARETT
Start date: March 2023
Phase: N/A
Study type: Interventional

Conventional endodontic treatment has been the treatment of choice for the management of signs and symptoms of mature permanent teeth with pulpal necrosis and periapical lesion with predictable and favorable results. However, treatment outcomes have not shown improvement or innovation in decades. The main objective of this study is to evaluate the clinical effectiveness of a regenerative endodontic procedure (cell-free and autologous protocol) versus conventional endodontics in the resolution of signs and symptoms of periapical lesion and pulp vitality-sensitivity in mature permanent teeth with a diagnosis of pulpal necrosis and periapical lesion.

NCT ID: NCT05289843 Not yet recruiting - Necrotic Pulp Clinical Trials

Rosmarinus Officinalis Versus 2.5%Sodium Hypochlorite as Root Canal Irrigants

Start date: May 2022
Phase: N/A
Study type: Interventional

To measure the Effect of Rosmarinus Officinalis versus 2.5%Sodium Hypochlorite as Root canal Irrigants on the Intensity of post-operative pain and Bacterial Reduction in asymptomatic necrotic Mandibular premolars.

NCT ID: NCT05230797 Not yet recruiting - Pulp Necroses Clinical Trials

Zincoxide-propolis vs Zincoxide-eugenol Pulpectomy

Start date: April 2022
Phase: Early Phase 1
Study type: Interventional

The clinical trial aims to evaluate the clinical and radiographic success of Zinc oxide- propolis versus Zinc oxide -Eugenol as obturating material in pulpectomy of non-vital primary teeth.

NCT ID: NCT05146713 Not yet recruiting - Necrotic Pulp Clinical Trials

Effect of Propolis Nanoparticles on Postoperative Pain and Bacterial Reduction in Mandibular Premolars

Start date: January 2022
Phase: Phase 2/Phase 3
Study type: Interventional

The aim of this study is to clinically compare the intensity of post-operative pain and the amount of bacterial reduction after using 20mg/ml propolis nanoparticles extract solution during chemo-mechanical preparation, versus 2.5% NaOCl, in asymptomatic necrotic mandibular premolars treated in a single visit.

NCT ID: NCT04728386 Not yet recruiting - Necrotic Pulp Clinical Trials

Postoperative Pain and Antibacterial Efficacy After Root Canal Irrigation With Curcumin or Sodium Hypochlorite

Start date: January 2021
Phase: N/A
Study type: Interventional

This study aims to compare the effect of 2% curcumin solution versus 2.5% sodium hypochlorite as irrigating solutions in necrotic mandibular molars in terms of postoperative pain and antibacterial effect.

NCT ID: NCT04587089 Not yet recruiting - Necrotic Pulp Clinical Trials

Efficacy of Guedes-Pinto Paste and CTZ Paste in the Non-instrumental Endodontic Treatment of Primary Teeth

Start date: August 20, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

The maintenance of the deciduous tooth until its physiological exfoliation occurs is one of the main objectives of pediatric dentistry. Endodontic treatment in deciduous teeth resulting from carious or traumatic lesions with pulpal involvement is often necessary and we often find it difficult to perform it, due to the difficult control of the child, the internal anatomy of the root canals, and root resorptions. The non-instrumental endodontic treatment technique (TENI) associated with antimicrobial drugs has advantages such as shorter chair time and less complexity than the conventional technique in which root canal instrumentation is performed. The objective of this study is to carry out a controlled and randomized clinical trial to compare the effectiveness of non-instrumental endodontic treatment (NIET) in primary teeth associated with the use of two filling pastes. 120 necrotic deciduous teeth of children aged between 3 and 6 years will be selected; and the teeth will be divided into two groups. In Group 1 and Group 2, the root canals will not be instrumented, just irrigated and filled with the respective pastes, CTZ and Guedes-Pinto. The radiographic aspects will be evaluated, considering the repair process, clinically will be evaluated: presence of fistula and mobility, the evaluations will be carried out in both groups on the day of treatment and in periods of 1, 3 and 6 months after treatment. The data obtained will be submitted to the Shapiro-Wilk normality test, where the statistical analysis that will be used for this study will be defined, adopting a significance level of 95% (p<0.05).

NCT ID: NCT04158232 Not yet recruiting - Clinical trials for Apical Periodontitis

Assessment of Regenerative Potential of Mature Permanent Teeth With Necrotic Pulps Using Two Revascularization Protocols. (In Vivo Study)

Start date: November 2, 2019
Phase: N/A
Study type: Interventional

Regenerative endodontic procedures have been used to successfully treat human mature permanent teeth with necrotic pulps and apical periodontitis. Many researchers have begun to apply regenerative endodontic procedures to mature teeth in adult patients. Several clinical case reports have shown complete resolution of signs and symptoms of pulp necrosis in mature teeth, even those with large periapical lesions, as well as signs of pulp canal obliteration. thevaim of this study is To assess the regenerative potential of mature permanent teeth with necrotic pulps with platelet-rich fibrin (PRF) and blood clot using radiographic and clinical methods.