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Dental Caries clinical trials

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NCT ID: NCT04475679 Active, not recruiting - Dental Caries Clinical Trials

Clinical Evaluation of Adhese Universal DC in the Indirect Restorative Therapy

Start date: September 4, 2020
Phase: N/A
Study type: Interventional

A post market clinical follow up study (PMCF) with Adhese Universal DC is planned to ensure the safety and efficacy of the product. It is a study with two arms. Inlays and onlays for molars and premolars will be luted with Adhese Universal DC or Adhese Universal.

NCT ID: NCT04446390 Active, not recruiting - Dental Caries Clinical Trials

Preventive Regimens With Herbal and Fluoride Toothpaste on Remineralization in High Caries Patients With Initial Lesions

Start date: January 1, 2021
Phase: N/A
Study type: Interventional

This study will be conducted to assess the effect of different preventive regimens using herbal toothpaste versus fluoride toothpaste on the management of remineralization and caries risk in high caries risk patients.

NCT ID: NCT04355000 Active, not recruiting - Dental Caries Clinical Trials

Comparative Evaluation of Effectiveness of Hall Technique and Resin Modified Glass Ionomer Cement in Controlling Occlusoproximal Caries in Primary Molars in Children

Start date: November 1, 2019
Phase: N/A
Study type: Interventional

•To investigate clinical and radiographic outcomes of Hall Technique and conventional restorative care using RMGIC in occulusoproximal carious lesions of primary molars in children.

NCT ID: NCT04351048 Active, not recruiting - Clinical trials for Dental Caries, Dental Pulp Exposure

Stepwise and One Step Techniques In Deep Dentin Lesion

Start date: December 12, 2016
Phase: N/A
Study type: Interventional

This double blind, randomized, controlled clinical trial aimed to observe the success of stepwise (SW) and one step (OneS) excavation techniques in the management of deep dentin caries. Additionally, evaluation of glass ionomer cement (GIC) as temporary restorative was also performed. For this purpose, forty participants were selected among the routine patients coming to university clinic. A permanent tooth having caries lesions penetrating to 75 percentage or more of dentin of patient were included. Randomization to SW and OneS groups were organized by coin method. The periphery of the cavities including enamel-dentin junction was cleaned until reach to hard dentin. Afterwards, selective removal to soft dentin on the pulpal side of the cavities was applied manually excavation and covered with pure calcium hydroxide and zinc oxide eugenol cement. GIC was used for temporary filling. This process was implemented both the first stage excavation of SW and OneS groups. Clinical and radiographic evaluations were performed at 6 months according to clinical signs and symptoms and radiographic sings using Periapical Index (PAI). Besides, temporary restorations were evaluated according to the of Ryge/Modified USPHS criteria. Following this evaluation, on the SW group, the cavities was re-entered and selective removal was applied up to firm dentin and pulp-capping were applied as mentioned above. In OneS group, temporary restoration was reduced as a base. All of the cavities were permanently restored with resin composite. Whole procedure was completed at one centre by a specialist, and control sessions was performed two experienced experts. Participants and experts were blinded in this study.

NCT ID: NCT04345263 Active, not recruiting - Carious Teeth Clinical Trials

Outcome of Full Pulpotomy Using Calcium Silicate Based Materials

pulpotomy
Start date: September 1, 2017
Phase: N/A
Study type: Interventional

Permanent teeth with carious pulp exposure and indicated for full pulpotomy will be treated using three different materials using aseptic technique and will be subsequently followed up clinically and radiographically at 6 months, 1 year and yearly up to 5 years.

NCT ID: NCT04342858 Active, not recruiting - Caries,Dental Clinical Trials

Prospective Randomized Controlled Trial for Prevention of Demineralization During Fixed Orthodontic Treatment

Start date: September 15, 2017
Phase: Phase 2
Study type: Interventional

Treatment with fixed orthodontic appliances is often associated with pain, which poses great challenges in the efficient brushing of the teeth thus making the teeth more vulnerable to plaque formation. Treatment duration with fixed orthodontic appliances usually extends to 18 months or even longer in some cases. This prolonged vulnerability to plaque formation frequently leads to demineralization of teeth. There is also an increase in the number of plaque retentive sites due to the fixed appliances, leading to a rapid change in the bacterial composition of the dental plaque, particularly in the number of acidogenic bacteria. The resulting enamel decalcification is also known as white spot lesions (WSLs), which is an early sign of demineralization of enamel. Enamel WSLs (EWSLs) can be observed even as early as four weeks from the start of fixed orthodontic treatment. The occurrence of EWSLs adjacent to the orthodontic brackets ranges from 15 to 85%. The incidence of EWSLs development is higher in orthodontic patients as compared to the development of similar lesions in non-orthodontic patients. These EWSLs are not aesthetically pleasing and is certainly unacceptable when it develops during fixed orthodontic treatment that is usually performed in patients who often seek such treatment to improve their aesthetics. Additionally, even if the outcome of fixed orthodontic treatment is superior from well-aligned teeth, aesthetics can be greatly compromised with EWSLs. Therefore, the prevention of such lesions is an important concern for orthodontists. Though professionally applied topical fluoride varnish helps in remineralization of EWSLs, an adequate supply of calcium and phosphate ions is essential for remineralization. Therefore, EWSLs on maxillary teeth could be prevented and remineralized by the use of advanced novel topical fluoride varnish with added calcium and phosphate-based delivery system.

NCT ID: NCT04320576 Active, not recruiting - Dental Caries Clinical Trials

Clinical Comparison of Bulk-fill Restorative and Nano-fill Resin Composite

Start date: May 1, 2013
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate the clinical performance of a nano-fill and a bulk fill resin composite in class II restorations.

NCT ID: NCT04279574 Active, not recruiting - Caries,Dental Clinical Trials

Clinical Performance of Chairside CAD/CAM Restorations

Start date: August 26, 2020
Phase: N/A
Study type: Interventional

This investigation will be a longitudinal clinical trial to study the long-term clinical performance of a resin cement for chairside CAD/CAM restorations. Lithium disilicate chairside CAD/CAM onlays will be adhesively bonded using a selective enamel etch technique with an adhesive. Full contour zirconia crowns will be cemented using a self-adhesive resin cement.

NCT ID: NCT04271150 Active, not recruiting - Dental Caries Clinical Trials

Efficiency of Different Modes of Universal Adhesive

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate and compare the clinical performance of a Universal adhesive's different application modes.

NCT ID: NCT04231383 Active, not recruiting - Clinical trials for Dental Caries in Children

Evaluation of the Relationship Between Dental Caries and Growth Parameters in Preschool Children

Start date: August 1, 2019
Phase:
Study type: Observational

Untreated dental caries are very common in preschool children. Pain and inflammation due to dental caries have been reported to affect eating and sleeping disorders, affecting growth and development. The aim of this study was to compare the changes in serum IGF-1 and IGFBP-3 levels, height and weight gain before and after treatment in patients with dental caries-related inflammation and pain in preschool children and to compare these children with children without dental caries. Thirty children aged between 3-6 years with dental caries with pulp were identified using ICDAS II and dmft index as the study group.30 children dental caries including pulp, will be included using the same indices as the control group. In the study group, serum IGF-1 and IGFBP-3 levels and anthropometric measurements will be determined before and at the 6th month after treatment. In the control group, serum IGF-1 and IGFBP-3 levels and anthropometric measurements will be determined at the 6th month following the first dental examination. IGF-1, IGFBP-3 and anthropometric measurements will be compared between first dental examination and 6th month values in the study and control groups, and between first dental examination and 6th month time points between the groups.