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Pregabalin Versus Dexmedetomidine for Delirium Prevention After Cardiac Surgery

Delirium Clinical Trial

Official title:
Pregabalin Versus Dexmedetomidine for Delirium Prevention After Cardiac Surgery: A Randomized Double-Blind Trial

Clinical Trial Summary

The aim of this study is to compare the effect of perioperative administration of pregabalin versus dexmedetomidine on the prevalence and lasting duration of delirium in elderly patients after cardiac surgery.

Clinical Trial Description

Pregabalin is a beta-isobutyl of GABA with chemical similarity to gabapentin . Pregabalin binds to the alpha-2-delta subgroup of calcium channels, thereby reducing excitatory neurotransmitter release and preventing hyperalgesia and central sensitization . Pregabalin is used as anticonvulsant but has also been used as analgesic for neuropathic pain and, lately, for postoperative pain, in an attempt to reduce opioid consumption and prevent progression to chronic pain. Dexmedetomidine with its broad range of effects including easily controllable sedation, analgesia, and anxiolysis still enables the caring medical team to interact with the patient. It reduces the activity while still maintaining the reactivity of neurons in the locus coeruleus. Therefore, it is an appealing alternative to traditional sedatives such as propofol and benzodiazepines. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05640479
Study type Interventional
Source Tanta University
Contact Islam Morsy, MD
Phone 00201093387374
Email eslam.morsy@med.tanta.edu.eg
Status Recruiting
Phase Phase 4
Start date December 15, 2022
Completion date May 15, 2023
View Details
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