Delirium, Dementia, Amnestic, Cognitive Disorders Clinical Trial
Official title:
The Regional Cerebral Oxygen Saturation and Both S100B and GFAP Proteins Serum Concentration in Patients Undergoing Primary Hip Arthroplasty.
Postoperative Cognitive Disorders (POCD) are common in hospitalized people > 60 year old,
especially in orthopedic patients. Etiology of POCD is complex, and in some aspects still
remains unclear. The role of thromboembolic events in etiology of POCD was discussed. The
incidence of such events in patients who underwent big joints arthroplasty can be as high as
40 to 60%, although some cases are subclinical. Thromboembolic material can block a blood
flow through a vessels in the brain. As a consequence cerebral neurons can be damaged or
destroyed. After neuronal damage specific substances, such as S100B protein, glial
fibrillary acidic protein (GFAP) and neuron-specific enolase (NSE) are released to the
blood. The serum concentrations of these biomarkers can be measured. Moreover, the block of
blood flow will decrease regional cerebral saturation in affected parts of the brain.
In this project the authors would like to analyze the correlation between the regional
cerebral saturation and serum concentration of both S100B protein and GFAP in orthopedic
patients scheduled to primary hip arthroplasty.
n/a
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Diagnostic
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