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Volatile Anesthetic Protection Of Renal Transplants 2 — VAPOR-2  

Delayed Graft Function Clinical Trial

Official title:
Volatile Anesthetic Protection Of Renal Transplants 2

Clinical Trial Summary

To compare the effect of a sevoflurane based anesthesia versus a propofol based anesthesia on the incidence of DGF in recipients of kidneys of donation after circulatory death (DCD) and donation after brain death (DBD) donors

Clinical Trial Description

Objective:

To compare the effect of a sevoflurane based anaesthesia versus a propofol based anaesthesia on the incidence of delayed graft function in recipients of DCD and DBD donor kidneys.

Study design:

Prospective randomized controlled European multicentre clinical trial with two parallel groups

Study population:

Patients ≥18 years scheduled for kidney transplantation with a kidney from a DBD or DCD donor

Intervention:

Patients will be included and randomised to one of the following groups:

Group 1 PROP (control): Propofol: a propofol-remifentanil based anaesthesia. Group 2 SEVO (intervention): Sevoflurane: a sevoflurane-remifentanil based anaesthesia.

Main study parameters:

DGF defined as need of dialysis the first week after transplantation excluding one time dialysis for hyperkalemia Acute rejection episodes within the first year after transplantation Graft and patient survival GFR at 3 and 12 months PNF defined as a permanent lack of function of the allograft Length of hospital stay Postoperative complications of all kind kidney biomarkers (urine/plasma) mechanisms of protection/immunomodulation with anestheticanaesthetic agents ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02727296
Study type Interventional
Source University Medical Center Groningen
Contact Gertrude J Nieuwenhuijs-Moeke, MD
Phone +31631623075
Email g.j.nieuwenhuijs-moeke@umcg.nl
Status Recruiting
Phase Phase 4
Start date April 1, 2017
Completion date December 2022
View Details
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