Clinical Trials Logo
  1. Home
  2. Delayed Cerebral Ischemia
  3. NCT06375889

Platelet Activation in Delayed Cerebral Ischemia Secondary to Aneurysmal Subarachnoid Hemorrhage — APICRASH  

Delayed Cerebral Ischemia Clinical Trial

Official title:
Platelet Activation in Delayed Cerebral Ischemia Secondary to Aneurysmal Subarachnoid Hemorrhage

Clinical Trial Summary

Aneurysmal subarachnoid haemorrhage is a complex pathology, the pathophysiology of which is still imperfectly understood. Its morbidity and mortality remain significant. In addition to the damage sustained by the brain in the immediate aftermath of aneurysmal rupture, which is inaccessible to life-saving treatment, a significant proportion of lesions occur at a distance from the initial event. Delayed cerebral ischaemia is one of the most morbid complications. It combines an inflammatory pattern with vascular dysfunction and neuronal excitotoxicity, leading to avoidable secondary neuronal loss. Vascular dysfunction is mediated by a loss of homeostasis between endothelial cells and figurative blood cells, including platelets. However, the interrelationship between these elements and the precise chronology of the dysfunction remain imperfectly described to date. It therefore seems appropriate to propose temporal monitoring of platelet activation kinetics over time, combined with concomitant collection of markers of endothelial damage, in order to clarify the vascular chronobiology of this pathology.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06375889
Study type Observational
Source Hospices Civils de Lyon
Contact Nicolas Chardon, MD;Msc
Phone 683396245
Email nicolas.chardon@chu-lyon.fr
Status Recruiting
Phase
Start date June 14, 2024
Completion date July 14, 2025
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06032533 - Remote Ischemic Conditioning in Aneurysmal SAH N/A
Completed NCT05131295 - Dapsone Use in Patients With Aneurysmal Subarachnoid Hemorrhage. Phase 3
Recruiting NCT04649398 - Cerebral Nimodipine Concentrations Following Oral, Intra-venous and Intra-arterial Administration
Completed NCT02320539 - MicroRNA Diagnostics in Subarachnoid Hemorrhage 2 N/A
Completed NCT03318783 - Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial Phase 1/Phase 2
Completed NCT03214705 - Role of CT Perfusion in Predicting Poor Outcome After Subarachnoid Hemorrhage
Completed NCT01187420 - Bilateral Bispectral Index (BIS) Study N/A
Terminated NCT03032471 - Swiss SOS MoCA - DCI Study
Not yet recruiting NCT05727657 - Satralizumab in Aneurysmal Subarachnoid Hemorrhage Early Phase 1
Active, not recruiting NCT04876638 - Minocycline for Aneurysmal Subarachnoid Hemorrhage (MASH) Phase 2
Terminated NCT02222727 - Effects of Donepezil on Regional Cerebral Blood Flow Following Aneurysmal Subarachnoid Haemorrhage Phase 2
Recruiting NCT05483751 - Micro- and Macrovascular Parameters in Delayed Cerebral Ischemia
Recruiting NCT04507178 - Improving Outcome in Subarachnoid Hemorrhage wIth Nadroparine Phase 2
Completed NCT01787123 - Randomized, Double-blind, Placebo-controlled Trial to Investigate Safety and Efficacy of Cerebrolysin™ in Patients With Aneurysmal Subarachnoid Hemorrhage Phase 2/Phase 3
Active, not recruiting NCT04998370 - Cerebrospinal Fluid Hemoglobin to Monitor for Aneurysmal Subarachnoid Hemorrhage Related Secondary Brain Injury
Active, not recruiting NCT02056769 - CT Perfusion Imaging to Predict Vasospasm in Subarachnoid Hemorrhage N/A