Clinical Impact of MI on Inhaled Antibiotic Adherence in Cystic Fibrosis

Status Completed

Clinical Trial Summary

Clinical Trial Description

Adherence to treatment is a major challenge in cystic fibrosis (CF). Motivational Interviewing (MI) is increasingly used to address this, but its effectiveness is unknown. We investigated the clinical impact of an MI intervention, delivered by a specifically trained pharmacist, on adherence to inhaled antibiotics (IA).

Adults with CF were recruited through the Regional CF Centre. A pharmacist trained in MI delivered three recorded MI sessions over 2 months, with follow up at 3, 4 and 6 months. Demographics, ppFEV1, BMI, adherence (IA collection rates) and additional antibiotic use were collected during the study and for 6 months prior. Treatment Quality and Satisfaction (TQSM), self-reported adherence (Moriskey Medication Adherence Scale-8 (MMAS-8)), Quality Of Life (CF Questionnaire-Revised (CFQ-R)) and sputum Pseudomonas aeruginosa (Pa) density were assessed at each study visit. Statistical analysis compared outcomes pre and post-intervention and variation during the intervention period. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04017559
Study type	Interventional
Source	Belfast Health and Social Care Trust
Contact
Status	Completed
Phase	N/A
Start date	October 22, 2014
Completion date	May 17, 2017

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