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In Vitro Model of the Cystic Fibrosis Bronchial Epithelium Via iPS Technology — PaCyFIC  

Cystic Fibrosis Clinical Trial

Official title:
Initiation of an in Vitro Model of the Cystic Fibrosis Bronchial Epithelium Via Induced Pluripotent Stem Cell Technology

Clinical Trial Summary

In order to further enable physiopathology studies, the aim of this project is to validate an in vitro model of cystic fibrosis created using induced pluripotent stemcell (iPS) differentiated bronchial epithelium from cystic fibrosis (CF) patients homozygous for the p.Phe508del mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) gene.

Clinical Trial Description

The investigator's primary objective is to generate iPS lines from 3 CF patients and from 3 healthy subjects. Secondary objectives include verification that cell lines express the CFTR gene according to their genotype, verification or relative production of the CFTR protein for each iPS line, and amplification of obtain iPS lines for aliquot creation to facilitate sharing. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03754088
Study type Observational
Source University Hospital, Montpellier
Contact
Status Completed
Phase
Start date November 5, 2018
Completion date April 25, 2019
View Details
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