A Study of Lung Clearance After Hypertonic Saline Delivery Using the tPAD Device

Cystic Fibrosis Clinical Trial

Official title: A Randomized Crossover Mucociliary Clearance Study of Aerosolized 7% NaCl Solution Administered Overnight by the tPAD Device to Subjects With Cystic Fibrosis

Status Completed

Clinical Trial Summary

The primary objective of this study is to determine whether a single overnight, eight-hour administration of a 7% NaCl solution delivered by the Parion Sciences transnasal Pulmonary Aerosol Delivery (tPAD) device has a significant effect on mucociliary clearance in subjects with cystic fibrosis, as compared to no treatment. This study will be conducted at the University of Pittsburgh Medical Center.

Clinical Trial Description

Cystic Fibrosis (CF) lung disease is caused by dehydration of airway secretions that leads to mucus adhesion, infection and airways inflammation. A simple means to restore hydration to CF airway surfaces is to inhale hypertonic (3-7% NaCl) saline, which osmotically draws water onto the airway surface. Rehydration of the lubricant layer of the airway surface liquid facilitates mucociliary clearance (MCC) and therefore the removal of inhaled infectious agents. Recent studies have described (1) the short term (two weeks) beneficial effects of inhaled hypertonic saline (HS) four times daily on pulmonary function, MCC, and quality of life and (2) the long term (one year) benefits of inhaled HS twice daily on lung function and pulmonary exacerbation frequency. Consequently, inhaled HS is now used by ~55% of patients with CF nationwide. Due to the large number of medications that CF patients use on a daily basis in conjunction with airway clearance techniques, there is a high treatment burden that results in decreased quality of life.

Both the Cystic Fibrosis Foundation and leading CF clinicians support the idea that the use of hypertonic saline is now a standard of care. The investigators believe the use of a specialized transnasal Pulmonary Aerosol Delivery (tPAD) device for administration of HS will improve on that standard of care by reducing the treatment burden during CF patients' waking hours, ensuring greater compliance and potentially improving the efficacy and tolerability of inhaled HS.

A previous deposition study with the tPAD, in six healthy adult subjects, demonstrated ~38% of the 7% HS aerosol emitted from the nasal cannula is deposited in the adult lungs, with no acute safety or tolerability issues (Parion Sciences Protocol PS-D100-102; Scott Donaldson, PI). This deposition efficiency matched that of the Pari LC Star used via the oral route, which was used as a standard of practice comparator. However, 7% HS nebulization by the tPAD resulted in a more peripheral deposition of the aerosol than the Pari LC Star comparator.

Previously, it has been shown that administration of 5 mL of 7% HS QID by the Pari LC Star leads to a significant improvement in the lung function in CF patients. The investigators estimate that this dosing regimen deposits ~400 mg of NaCl per day but requires four ~18 minute administrations (deposition rate = 5.8 mg/min). Although HS is generally well tolerated in the CF population, intolerance does occur and is largely related to the rate of NaCl delivery to the oropharynx and airway surfaces. As nebulizer devices capable of administering aerosols through a nasal cannula are not currently available, Parion Sciences has designed a customized nebulizer spacer that entrains the aerosol from an approved and marketed Aerogen Aeroneb Pro vibrating mesh nebulizer into a nasal cannula without significant "rain out" or dripping from the cannula. The tPAD system being utilized has an output rate of ~50 ul/min, and so emits ~3.5 mg/min of NaCl and deposits ~1.3 mg/min in the lung (38% deposition efficiency). If used overnight for 8 hours, the investigators estimate that 640 mg NaCl will be deposited in the lung. Therefore, the investigators project that this novel administration system has the capacity to deliver approximately 50% greater mass of NaCl to the lung when used overnight, compared to 4 times a day treatment with a standard oral nebulizer, thereby potentially increasing efficacy. However, because the lung deposition rate is less than 25% that of the standard oral nebulizer, the investigators anticipate that the tPAD will also be better tolerated and will eliminate the need for daytime HS treatments. In this study, the investigators will explore the safety, tolerability and effect on mucociliary and absorptive clearance rates of a 7% HS solution administered continuously overnight via the transnasal route.

The tPAD is a non-significant risk device which is composed of a 510K approved Aerogen Aeroneb Pro vibrating mesh nebulizer with a custom nebulization chamber that allows for connection of a standard nasal cannula. Protocol PS-D201 is funded by NIH Grant 2R44HL110502-02 "Hypertonic Saline for Cystic Fibrosis". ;

Related Conditions & MeSH terms

• Cystic Fibrosis
• Fibrosis

• NCT number: NCT02141191
• Study type: Interventional
• Source: University of Pittsburgh
• Status: Completed
• Phase: Phase 1
• Start date: June 2014
• Completion date: October 2015