Cystic Fibrosis Clinical Trial
Official title:
Airway Infection, Inflammatory Markers and Exercise Capacity in Patients With Cystic Fibrosis and at Least One G551D Mutation Taking VX770 (Ivacaftor)
Ivacaftor will restore CFTR function in treated CF patients with the G551D mutation. Improvement in ventilation, salt balance and well-being will contribute to better exercise capacity at all levels of lung function. While potential improvements may be variable across the spectrum of lung function, even small gains at low levels of FEV1 may have significant benefit for some subjects.
The Alfred CF Service is ready to initiate therapy with VX-770 in it's cohort. Investigators
therefore have an opportunity to examine correlates between improvements in lung function,
exercise capacity, inflammatory markers and indices of wellbeing in CF that may not be
repeatable in a single cohort.
Investigators propose a double-blind, placebo-controlled cross-over study of 20 patients
currently awaiting initiation of ivacaftor therapy. Patients enrolled in the study will be
asked to undergo screening (day -28), and baseline assessments (day 0) and re-assessment
studies (day 28) after treatment period 1, followed by baseline assessment at the beginning
of treatment period 2 (day 56) and at the conclusion of treatment period 2 (day 84). A
further assessment (day 224) will be performed 140 (+/-7) days following commencement on
open label Ivacaftor.
After satisfying eligibility criteria, subjects will be randomly assigned to initial active
treatment or placebo following a 4 week run-in period. After completion of period 1 and a 4
week washout period, subjects will cross-over to the alternative treatment. After 4 weeks of
period 2, subjects will undergo final assessment as shown in the diagram below. However
participants choosing not to continue taking ivacaftor in a Named Patient Program or another
similar program run by Vertex Pharmaceuticals, Inc., ('Vertex'), at the end of the study
period will be required to undergo a Safety Follow-Up visit 28 days after the final dose of
study drug. Safety Follow-Up assessments will not include the CPET.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Basic Science
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