A Novel, Comprehensive Approach to Post-stroke Gait Rehabilitation

Status Recruiting

Clinical Trial Summary

The goal of this project is to determine the feasibility and optimal parameters of a novel, comprehensive approach to gait training in individuals with chronic stroke. The comprehensive approach includes biofeedback-based gait training and aerobic exercise intensity-based gait training.

Clinical Trial Description

The goal of this project is to determine the feasibility and optimal parameters of a novel, comprehensive approach to gait training in individuals with chronic stroke. Current post-stroke gait training follows two distinct approaches that target different domains of gait dysfunction (as defined by the International Classification of Functioning, Health, and Disability). Biofeedback-based gait training is typically employed to treat walking pattern impairments (e.g., kinematic deviations relative to able-bodied controls); whereas, aerobic exercise intensity-based gait training is the current gold-standard to treat walking activity limitations (e.g., slow walking speeds). Here, the investigators propose to test the impact of combining these approaches into a single intervention to work toward the development of a more effective, comprehensive approach to gait rehabilitation for persons post-stroke. The central hypothesis is that individuals with chronic stroke have the capacity to use biofeedback to reduce kinematic gait deviations while walking at a range of recommended aerobic exercise intensity zones. Aim 1 will identify the gait biofeedback variable that elicits the largest reduction in interlimb asymmetry in persons post-stroke. Aim 2 will determine the capacity for persons post-stroke to make biofeedback-driven reductions in their interlimb asymmetry while walking at three different aerobic exercise intensities. Participants with chronic stroke in Aim 1 will each complete three experimental sessions and participants in Aim 2 will complete 1 experimental session. Biomechanical analyses and physiologic assessments will be used across both aims to test our working hypotheses. The investigators expect to show that biofeedback of paretic propulsion leads to the greatest reduction in interlimb asymmetry and that participants have the capacity to make biofeedback-driven interlimb asymmetry reductions while walking at all three aerobic intensities, but the magnitude of reduction will be the largest at a moderate aerobic walking intensity. The proposed work is innovative because it will be the first to test the relative effects of different gait biofeedback variables on whole lower extremity kinematics in persons post-stroke and test a novel combination of two well-established gait training approaches (biofeedback- and intensity-based) for neurologic patient populations. This is a critical next step in moving the post-stroke gait rehabilitation field forward. If successful, this line of work stands to significantly improve the current standard of care in gait rehabilitation post-stroke. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04411303
Study type	Interventional
Source	University of Southern California
Contact	Kristan Leech, PT, DPT, PhD
Phone	(323) 442-1583
Email	kleech@pt.usc.edu
Status	Recruiting
Phase	Phase 1
Start date	June 9, 2021
Completion date	December 14, 2025

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT03605381` - MORbidity PRevalence Estimate In StrokE
Recruiting	`NCT04437251` - Effect of Brain Stimulation on Stepping Performance in Stroke Survivors and Healthy Adults	N/A
Recruiting	`NCT04530955` - Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS)	N/A
Recruiting	`NCT04042961` - Reactive Balance Training and Fitness	N/A
Completed	`NCT04567472` - HEADS: UP Online Psychological Self-management Intervention: Feasibility 2	N/A
Completed	`NCT00226096` - Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage	N/A
Completed	`NCT03863678` - Effects of Dry Needling on Spasticity, Functions, Balance and Independence Level in Patients With Stroke	N/A
Not yet recruiting	`NCT06241677` - Intravenous Thrombolytic Therapy in Acute Ischemic Stroke Patients on DOAC	N/A
Recruiting	`NCT05515237` - Constraint-Induced Movement Therapy Plus Sensory Components After Stroke	N/A
Completed	`NCT04921683` - The Use of LIFUP in Chronic Disorders of Consciousness	N/A
Recruiting	`NCT05847595` - Implicit Versus Explicit Motor Training for Upper Extremity Rehabilitation in Chronic Stroke Patients	N/A
Completed	`NCT03956693` - Helping Ease Anxiety and Depression Following Stroke	N/A
Completed	`NCT03561246` - Incline Training to Personalize Motor Control Interventions After Stroke	N/A
Recruiting	`NCT04829071` - Cognition and Motor Learning Post-stroke	Early Phase 1
Recruiting	`NCT05492513` - Constraint-Induced Movement Therapy for Adults Post-Stroke With Mild Upper Extremity Impairment	N/A
Completed	`NCT03602313` - Biomechanical Gait Analysis in Patients Post-Stroke	N/A
Recruiting	`NCT05174676` - Robotic Enhanced Error Training of Upper Limb Function in Post-stroke Patients	N/A
Completed	`NCT00396708` - Wearable Robotic Functional Assistance for Stroke Rehabilitation	N/A
Completed	`NCT02444637` - Open Label Trial of Rivastigmine Patch in Subjects With Mild to Moderate Stage AD Having Coexisting svCVD	Phase 4
Completed	`NCT05311384` - Application of a Reimbursable Form of Constraint-Induced Movement Therapy for Upper Extremity	N/A