Cushing Syndrome Clinical Trial
Official title:
Skin Microcirculation Evaluation With Nailfold Capillaroscopy in Cushing's Syndrome Patients
This cross-sectional, single-center study will assess the microvascular function using a nailfold video-capillaroscopy in patients with endogenous Cushing syndrome.
Endogenous Cushing's syndrome (CS) is associated with increased macrovascular diseases and
impaired endothelial function. There is no clear data about the effects of hypercortisolism
on microcirculation.
The primary aim of this study is to evaluate the peripheric microvascular area in patients
with Cushing's syndrome. The association of microvascular changes with present comorbidities
(diabetes, hypertension, etc.) and disease activation will be evaluated.
Method:
Cushing syndrome patients admitted to our clinic will be included in this study for the next
six months after given informed consent.
The following clinical laboratory parameters will be evaluated as cross-sectionally.
Previous medical history, available laboratory parameters (fasting plasma glucose, HbA1c,
total cholesterol, triglyceride, HDL, LDL, creatine, AST, ALT, complete blood count, ACTH,
dexamethasone suppression tests (1 mg- 2mg), urine free cortisol, FSH, LH, total
testosterone, estradiol, IGF-1, TSH, free T3, free T4, prolactin), radiologic images (Cranial
MRI and Adrenal MRI) will be recorded from medical charts.
Nailfold microcirculation will be evaluated with video-capillaroscopy: it is a non-invasive
atraumatic assessment of the morphology and some functional aspects of cutaneous capillaries.
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