Cryptosporidiosis Clinical Trial
Official title:
Pilot Intervention Trial of Ceramic Water Filters to Reduce the Burden of Cryptosporidium in Household Drinking Water in Rural Kenya.
The aim of the study is to examine the efficacy of ceramic water filters to reduce the burden of waterborne diarrheal illness among infants in selected villages in Kenya. In Kenya very young children are given drinking water or water is used in reconstitution of their food. We hypothesize that ceramic water filters will remove Cryptosporidium from drinking water reducing infection in infants.
Diarrhea is a major cause of illness among children in Africa. Cryptosporidium is a protozoan waterborne diarrheal pathogen resistant to chlorine. Ceramic filters are effective at improving drinking water quality, including removal of protozoa. In a recent preliminary analysis of >22,000 children <5 years enrolled in the Global Enterics Multi-Center Study (GEMS) case-control study of moderate-to-severe diarrhea, Cryptosporidium was identified as a leading cause of diarrhea in infants across all four participating African sites. This pilot is the first Cryptosporidium specific intervention trial of household ceramic water filters to reduce the burden of cryptosporidiosis acquired through drinking water in rural Kenya. ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT00057486 -
Interleukin 12 (IL-12) for the Treatment of Cryptosporidiosis in AIDS Patients
|
Phase 1/Phase 2 | |
| Completed |
NCT00507871 -
Transmission and the Respiratory Tract in Cryptosporidiosis
|
N/A | |
| Terminated |
NCT00001162 -
Parasitic Infections of the Gastrointestinal Tract
|
N/A | |
| Recruiting |
NCT05208970 -
Cryptosporidium Species in Sohag Governorate
|
||
| Recruiting |
NCT04332705 -
Cryptosporidium Infection and Human Colorectal Cancer
|
||
| Active, not recruiting |
NCT02764918 -
Cryptosporidiosis and Enteropathogens in Bangladesh
|
||
| Terminated |
NCT00004986 -
Safety and Effectiveness of Nitazoxanide for the Treatment of Cryptosporidiosis in AIDS Patients
|
Phase 3 | |
| Completed |
NCT04103216 -
Treatment of Cryptosporidiosis
|
N/A | |
| Terminated |
NCT03341767 -
A Phase 2A Evaluation of the Safety, Tolerability, Pharmacokinetics, Efficacy of Clofazimine (CFZ) in Cryptosporidiosis
|
Phase 2 | |
| Completed |
NCT01699841 -
Breast Milk Composition and HIV-exposed/Unexposed Early Infant Growth and Infectious Disease Events
|
N/A | |
| Active, not recruiting |
NCT00002158 -
A Study to Evaluate the Use of Nitazoxanide to Treat Cryptosporidiosis
|
N/A | |
| Completed |
NCT00055107 -
Nitazoxanide for the Treatment of Chronic Diarrhea in HIV Infected Children
|
Phase 1/Phase 2 | |
| Completed |
NCT00002027 -
Protocol For the Treatment of Cryptosporidiosis in AIDS Patients With Diclazuril (R64,433)
|
N/A | |
| Completed |
NCT00000980 -
A Study of Spiramycin in the Treatment of Patients With AIDS-Related Diarrhea
|
Phase 1 | |
| Terminated |
NCT00001128 -
Treatment of Chronic Cryptosporidiosis in AIDS Patients
|
N/A | |
| Completed |
NCT00002264 -
The Effectiveness of Cow's Milk Immune Globulin in the Treatment of AIDS-Related Diarrhea
|
N/A | |
| Completed |
NCT00002328 -
Azithromycin in the Treatment of Cryptosporidiosis in Patients Who Have Not Had Success With Other Drugs
|
N/A | |
| Completed |
NCT00001081 -
A Study of Nitazoxanide in Patients With AIDS and Diarrhea Caused by Cryptosporidium
|
Phase 2 | |
| Completed |
NCT00002278 -
A 28-Day Study of Diclazuril in the Treatment of Cryptosporidiosis in Patients With AIDS
|
N/A | |
| Completed |
NCT00002062 -
Open-Label "Compassionate" Use Study of Spiramycin for the Treatment of Diarrhea Due to Chronic Cryptosporidiosis in Immunocompromised Patients
|
N/A |