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Cryptosporidiosis clinical trials

View clinical trials related to Cryptosporidiosis.

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NCT ID: NCT03341767 Recruiting - Cryptosporidiosis Clinical Trials

A Phase 2A Evaluation of the Safety, Tolerability, Pharmacokinetics, Efficacy of Clofazimine (CFZ) in Cryptosporidiosis

Start date: December 14, 2017
Phase: Phase 2
Study type: Interventional

This study evaluates the safety, tolerability, pharmacokinetics, and efficacy of treating Cryptosporidiosis in HIV positive patients with Clofazimine. Half of the HIV positive patients with Cryptosporidiosis enrolled will be treated with Clofazimine while the other half will be given placebo. An additional group of HIV positive patients without Cryptosporidium infection or diarrhea will be given Clofazimine to assess the differences in pharmacokinetics between HIV positive patients with and without Cryptosporidiosis and diarrhea.

NCT ID: NCT02764918 Active, not recruiting - Cryptosporidiosis Clinical Trials

Cryptosporidiosis and Enteropathogens in Bangladesh

Start date: January 2014
Phase:
Study type: Observational

The purpose of this study is to investigate the incidence of Cryptosporidiosis in Bangladeshi children and describe the acquired immune response to the pathogen as well investigate the potential of human genetic susceptibility.

NCT ID: NCT01699841 Completed - HIV Clinical Trials

Breast Milk Composition and HIV-exposed/Unexposed Early Infant Growth and Infectious Disease Events

Start date: April 2012
Phase: N/A
Study type: Observational

The purpose of this study is to understand how breast milk may protect infants from infection and promote favorable immunological, growth and development outcomes. By following mothers and their infants, we will evaluate the important interactions between infant immune responses and infectious disease events in relation to breast milk composition and feeding patterns. Our aim is to identify a set of predictive factors corresponding to healthy early infant growth and development in this setting in Northern Tanzania.

NCT ID: NCT01695304 Not yet recruiting - Cryptosporidiosis Clinical Trials

Trial of Ceramic Water Filters to Reduce Cryptosporidium Infection in Kenya

Start date: February 2013
Phase: N/A
Study type: Interventional

The aim of the study is to examine the efficacy of ceramic water filters to reduce the burden of waterborne diarrheal illness among infants in selected villages in Kenya. In Kenya very young children are given drinking water or water is used in reconstitution of their food. We hypothesize that ceramic water filters will remove Cryptosporidium from drinking water reducing infection in infants.

NCT ID: NCT00507871 Completed - Cryptosporidiosis Clinical Trials

Transmission and the Respiratory Tract in Cryptosporidiosis

Start date: October 2007
Phase: N/A
Study type: Observational

Cryptosporidium is an intestinal parasite that causes diarrhea in children and adults. In addition to infection of the stomach, this parasite can infect the respiratory system causing a cough and/or problems breathing. This study will enroll 480 children between the ages of 9 and 36 months who come to Mulago Hospital for treatment of diarrhea. Researchers believe a large number of children with diarrhea and cough will have the parasite present in their sputum (mucus coughed up). Researchers also believe that children who have respiratory tract cryptosporidiosis may have a cough, increased number of breaths per minute, and/or a lower oxygen level. Blood, stool, saliva, and sputum samples will be collected from all children in the study and tested for Cryptosporidium. Children too young to provide a sputum sample will have a tube placed to collect a mucus sample from the lungs. Study participation may be as short as 4 hours or as long as 2 days depending on each child's health.

NCT ID: NCT00057486 Terminated - HIV Infections Clinical Trials

Interleukin 12 (IL-12) for the Treatment of Cryptosporidiosis in AIDS Patients

Start date: September 1997
Phase: Phase 1/Phase 2
Study type: Interventional

There is no proven effective treatment for chronic diarrhea caused by the parasite Cryptosporidium in advanced AIDS. This trial will test the safety of interleukin-12 (IL-12) as part of a combination therapy for this parasite.

NCT ID: NCT00055107 Completed - HIV Infections Clinical Trials

Nitazoxanide for the Treatment of Chronic Diarrhea in HIV Infected Children

Start date: n/a
Phase: Phase 1/Phase 2
Study type: Interventional

Cryptosporidium parvum (C. parvum) is a parasite that can cause chronic diarrhea and is a significant problem for HIV infected children in developing countries. C. parvum infection can be treated with the drug nitazoxanide (NTZ). However, NTZ has not been tested in HIV infected children. The purpose of this study is to test the safety of NTZ in HIV infected children who have chronic diarrhea caused by C. parvum. Study hypothesis: Twice-daily NTZ is safe and well tolerated in HIV infected infants, children, and adolescents with chronic diarrhea caused by C. parvum infection.

NCT ID: NCT00004986 Terminated - HIV Infections Clinical Trials

Safety and Effectiveness of Nitazoxanide for the Treatment of Cryptosporidiosis in AIDS Patients

Start date: February 2000
Phase: Phase 3
Study type: Interventional

The purpose of this study is to see if it is safe and effective to treat cryptosporidiosis in AIDS patients with nitazoxanide.

NCT ID: NCT00002328 Completed - HIV Infections Clinical Trials

Azithromycin in the Treatment of Cryptosporidiosis in Patients Who Have Not Had Success With Other Drugs

Start date: n/a
Phase: N/A
Study type: Interventional

To provide azithromycin for the treatment of individual patients with proven cryptosporidiosis whose disease has persisted or progressed despite prior therapies.

NCT ID: NCT00002278 Completed - HIV Infections Clinical Trials

A 28-Day Study of Diclazuril in the Treatment of Cryptosporidiosis in Patients With AIDS

Start date: n/a
Phase: N/A
Study type: Interventional

To evaluate the safety and efficacy of diclazuril capsules as a treatment for cryptosporidial related diarrhea in AIDS patients who have been treated in the double-blind study # JRD 64,433/1101 and have relapsed, or de-novo patients who have been diagnosed with cryptosporidial related diarrhea and who meet the inclusion and exclusion criteria of this protocol.