CRP/Albumin Ratio as a Predictive Inflammatory Marker for Postoperative SIRS and/or Sepsis

Crp Clinical Trial

Official title:
C-Reactive Protein / Albumin Ratio as a Predictive Inflammatory Marker for Postoperative Systemic Inflammatory Response Syndrome and/or Sepsis in Polytraumatized Patients in ICU

Status Recruiting

Clinical Trial Summary

The goal of this observational study is to determine the value of CRP/Albumin Ratio as an inflammatory marker for predicting the development of postoperative Systemic Inflammatory Response Syndrome and/or Sepsis in polytraumatized patients admitted to Intensive care unit. The main question it aims to answer is whether CRP/Albumin Ratio can be used as predictive inflammatory marker for postoperative Systemic Inflammatory Response Syndrome and/or Sepsis or not.

Clinical Trial Description

The development of postoperative Systemic Inflammatory Response Syndrome (SIRS) or Sepsis is a very serious complication that has been associated with high morbidity, mortality, and increased length of inpatient stay. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. As surgical interventions lead to well-understood metabolic, neuroendocrine, and immune responses, the stress responses to surgery contribute to increased postoperative complications mostly caused by increased levels of Pro-inflammatory cytokines in response to surgical injury, which leads to changes of circulating acute phase proteins, such as albumin and C-reactive protein (CRP). The CRP to albumin ratio (CAR) is a new index calculated by dividing CRP by the albumin level. It has been assumed to have predictive value in determining morbidity and mortality in many critical diseases. ;

Study Design

Related Conditions & MeSH terms

Crp
Sepsis
Systemic Inflammatory Response Syndrome

Clinical Trial Details

NCT number	NCT06050759
Study type	Observational
Source	Ain Shams University
Contact	Fathy Tash, Professor
Phone	+20226857539
Email	REC-FMASU@med.asu.edu.eg
Status	Recruiting
Phase
Start date	December 1, 2023
Completion date	February 1, 2025

View Details

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