Crohn Disease Clinical Trial
Official title:
Comprehensive DNA Methylation Profiling of Inflammatory and Non-Inflammatory Mucosa in Crohn's Disease
Verified date | August 2017 |
Source | Jinling Hospital, China |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
Previous studies have indicated that abnormal DNA methylation frequently occurs in the mucosa in Crohn's disease. Comprehensive DNA methylation profiling of the inflamed and non-inflamed ileal mucosa of patients with Crohn's disease was performed. Genome-wide DNA methylation was determined using the Illumina HumanMethylation 850k BeadChip.
Status | Recruiting |
Enrollment | 14 |
Est. completion date | September 30, 2017 |
Est. primary completion date | September 30, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 60 Years |
Eligibility |
Inclusion Criteria: - Active Crohn's disease(CDAI score= 150) Exclusion Criteria: - No ileal lesions - Under treatment of immunomodulators, biologic agents or steroids |
Country | Name | City | State |
---|---|---|---|
China | Jinling Hospital | Nanjing | Jiangsu |
Lead Sponsor | Collaborator |
---|---|
Jinling Hospital, China |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Intestinal inflammation under colonoscopy | Intestinal ulcer or enteritisis observed under colonoscopy | Jan 2017 to Sep 2017 | |
Secondary | CDAI | Crohns Disease Activity Index is measured. | Jan 2017 to Sep 2017 |
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